Sugi Predict

Sugi Predict / Compounds / SCHEMBL844312

SCHEMBL844312

SCHEMBL844312

O=Cc1cccc2cnccc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP2D6 P10635 4/20 0.53
▸ CYP3A4 P08684 4/20 0.53
▸ CYP1A2 P05177 3/20 0.53
▸ LMNA P02545 2/20 0.53
▸ CYP2C19 P33261 2/20 0.53
▸ KDM4E B2RXH2 2/20 0.53
▸ CYP2C9 P11712 1/20 0.53
▸ MAPKAPK2 P49137 1/20 0.53
▸ HTT P42858 1/20 0.53
▸ ERN1 O75460 1/20 0.50
▸ CYP19A1 P11511 2/20 0.46
▸ CYP11B1 P15538 2/20 0.46
▸ CYP11B2 P19099 2/20 0.46
▸ CCNT1 O60563 1/20 0.44
▸ CDK9 P50750 1/20 0.44
▸ HASPIN Q8TF76 1/20 0.44
▸ PIP4K2A P48426 1/20 0.42
▸ TRPV1 Q8NER1 1/20 0.41
▸ DAO P14920 1/20 0.41
▸ PRKD3 O94806 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29935732 1.00 CYP2D6 (0.53) CYP2D6CYP3A4CYP1A2LMNACYP2C19
SCHEMBL1071957 0.85 TNF (0.49) CYP2D6CYP3A4CYP1A2LMNACYP2C19
SCHEMBL29952841 0.85 TNF (0.49) CYP2D6CYP3A4CYP1A2LMNACYP2C19
SCHEMBL19153908 0.84 IKBKE (0.48) CYP2D6CYP3A4CYP1A2LMNACYP2C19
SCHEMBL587500 0.82 ERN1 (0.50) CYP2D6CYP3A4CYP1A2LMNACYP2C19
SCHEMBL1240616 0.81 LMNA (0.53) CYP2D6CYP3A4CYP1A2LMNACYP2C19
SCHEMBL11882678 0.78 HTT (0.54) CYP2D6CYP3A4CYP1A2LMNACYP2C19
SCHEMBL22319877 0.76 CYP1A2 (0.55) CYP2D6CYP3A4CYP1A2LMNACYP2C19
SCHEMBL1351597 0.76 ERN1 (0.50) LMNAKDM4EERN1PRKCIPRKCZ
SCHEMBL2010981 0.76 MEN1 (0.42) CYP2D6CYP3A4CYP1A2LMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 253 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106699660-B A kind of Ho3+Detection reagent and its preparation method and application 山西大学 2019-07-23 — — CN claimed
CN-109535167-A A kind of 1,8- naphthalimide derivative and its synthetic method and application 山西大学 2019-03-29 — — CN claimed
CN-106699660-A Detection reagent for Ho<3+> and preparation method and application thereof 山西大学 2017-05-24 — — CN claimed
CN-102316869-A The treatment method for cancer AMC AMSTERDAM 2012-01-11 — — CN claimed
CN-1218472-A Pharmaceutically useful compounds ASTRA PHARMA PROD (GB) 1999-06-02 — — CN claimed
US-12435040-B2 1,3-substituted cyclobutyl derivatives and uses thereof BAUSCH + LOMB IRELAND LIMITED (IE) 2025-10-07 — — US disclosed
US-20250025443-A1 COMPOUNDS AND METHODS FOR TREATING CORONA VIRUSES Clear Creek Bio, Inc. (US) 2025-01-23 — — US disclosed
CN-119143724-A Alkynyl substituted pyrazole compound and preparation method and application thereof 江苏开元药业有限公司 2024-12-17 — — CN disclosed
CN-118955375-A Tetraphenyl ethylene-isoquinoline compound and preparation method and application thereof 五邑大学 2024-11-15 — — CN disclosed
CN-118727264-A Isoquinoline micro-nanofiber membrane and preparation method and application thereof 五邑大学 2024-10-01 — — CN disclosed
US-20240308965-A1 1,3-SUBSTITUTED CYCLOBUTYL DERIVATIVES AND USES THEREOF JPMORGAN CHASE BANK, N.A., AS SUCCESSOR AGENT 2024-09-19 — — US disclosed
CN-115515956-B Benzimidazole derivative, and preparation method and medical application thereof 深圳信立泰药业股份有限公司 2024-06-25 — — CN disclosed
EP-1305295-A1 IMIDAZOLE DERIVATIVES Pfizer Products Inc. (US) 2003-05-02 — — EP disclosed
US-20030083352-A1 Synthesis of imidazole intermediates PFIZER INC. 2003-05-01 — — US disclosed
WO-2003013532-A1 CHIRAL DINAPSOLINE PURDUE RESEARCH FOUNDATION (US) 2003-02-20 — — WO disclosed
US-20020119963-A1 Imidazole derivatives PFIZER PRODUCTS INC. 2002-08-29 — — US disclosed
WO-2002013827-A1 PROCESS FOR THE PREPARATION OF DINAPSOLINE PURDUE RESEARCH FOUNDATION (US) 2002-02-21 — — WO disclosed
WO-2002010141-A1 IMIDAZOLE DERIVATIVES PFIZER PRODUCTS INC. (US) 2002-02-07 — — WO disclosed
EP-0632808-A1 ANTIVIRAL PEPTIDES Pfizer Limited (GB) 1995-01-11 — — EP disclosed
WO-1993019059-A1 ANTIVIRAL PEPTIDES PFIZER LIMITED (GB) 1993-09-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12435040-B2 1,3-substituted cyclobutyl derivatives and uses thereof TRPV1, TRPV3, TRPV2 CYP2D6 2256/4885CYP3A4 2016/4885CYP1A2 1653/4885
US-20030083352-A1 Synthesis of imidazole intermediates CDK1, CDK2, CDK3 CYP2D6 910/4885CYP3A4 589/4885CYP1A2 859/4885
US-20240308965-A1 1,3-SUBSTITUTED CYCLOBUTYL DERIVATIVES AND USES THEREOF TRPV1, TRPV3, TRPV2 CYP2D6 2256/4885CYP3A4 2016/4885CYP1A2 1653/4885
US-20020119963-A1 Imidazole derivatives CDK1, CDK3, CDK2 CYP2D6 2451/4885CYP3A4 2331/4885CYP1A2 2912/4885
US-20250025443-A1 COMPOUNDS AND METHODS FOR TREATING CORONA VIRUSES ACE, PREP, PEPD CYP2D6 3060/4885CYP3A4 1326/4885CYP1A2 2421/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.