Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.40 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | CASP2 | P42575 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8442502 | 0.87 | FYN (0.42) | FYNCYP2D6ALDH1A1LMNA | |
| SCHEMBL8442901 | 0.75 | NPC1 (0.46) | ALDH1A1POLBMAPT | |
| SCHEMBL8443204 | 0.74 | TSHR (0.41) | ROCK2ROCK1ACHELGALS1CYP1A2 | |
| SCHEMBL8440438 | 0.73 | TSHR (0.46) | ROCK2ROCK1ACHELGALS1CYP1A2 | |
| SCHEMBL8443922 | 0.71 | TSHR (0.50) | ROCK2ROCK1ACHELGALS1CYP1A2 | |
| SCHEMBL8441352 | 0.71 | FYN (0.41) | FYNCYP1A2CYP2D6ALDH1A1LMNA | |
| SCHEMBL8440006 | 0.70 | ALDH1A1 (0.41) | CYP2D6ALDH1A1LMNA | |
| SCHEMBL8441235 | 0.68 | TSHR (0.44) | ROCK2ROCK1ACHELGALS1CYP1A2 | |
| SCHEMBL8444324 | 0.66 | USP2 (0.41) | FYNALDH1A1 | |
| SCHEMBL8444336 | 0.66 | L3MBTL1 (0.44) | FYNCYP2D6ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5968985-A | INHIBITORS OF SODIUM ION/HYDROGEN ION EXCHANGE IN CELLS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-19 | — | — | US | disclosed |
| EP-0773927-A2 | BENZOYLGUANIDINE DERIVATIVES AS MEDICAMENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996004241-A2 | BENZOYLGUANIDINE DERIVATIVES AS MEDICAMENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-15 | — | — | WO | disclosed |