Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 4/20 | 0.39 |
| ▸ | ASAH1 | Q13510 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8439464 | 0.85 | KMT2A (0.43) | PLA2G7ASAH1LMNATP53KMT2A | |
| SCHEMBL8443370 | 0.84 | PLA2G7 (0.39) | PLA2G7ASAH1POLBGAAKMT2A | |
| SCHEMBL8440271 | 0.79 | KMT2A (0.44) | PLA2G7ASAH1LMNAKMT2AMAPT | |
| SCHEMBL8440268 | 0.79 | KMT2A (0.44) | PLA2G7ASAH1LMNAKMT2AMAPT | |
| SCHEMBL8439466 | 0.78 | KMT2A (0.43) | PLA2G7ASAH1POLBLMNAKMT2A | |
| SCHEMBL8441538 | 0.75 | TRPV1 (0.49) | ASAH1POLBGAALMNAKMT2A | |
| SCHEMBL8776909 | 0.73 | TRPV1 (0.49) | ASAH1GAALMNAKMT2ATRPV1 | |
| SCHEMBL8772461 | 0.73 | TRPV1 (0.49) | ASAH1GAALMNAKMT2ATRPV1 | |
| SCHEMBL8443487 | 0.73 | KMT2A (0.48) | PLA2G7ASAH1POLBGAALMNA | |
| SCHEMBL8104077 | 0.68 | TRPV1 (0.52) | ASAH1POLBGAALMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |