Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 3/20 | 0.44 |
| ▸ | RAD52 | P43351 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2823242 | 0.82 | CYP1A2 (0.68) | HTTSMN1; SMN2CYP1A2ALDH1A1KDM4E | |
| SCHEMBL21046542 | 0.81 | HTT (0.66) | HTTSMN1; SMN2CYP1A2ALDH1A1KDM4E | |
| SCHEMBL8639778 | 0.78 | NAAA (0.60) | HTTSMN1; SMN2CYP1A2ALDH1A1KDM4E | |
| SCHEMBL11216405 | 0.77 | KDM4E (0.68) | HTTSMN1; SMN2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL19418228 | 0.76 | ALDH1A1 (0.63) | HTTSMN1; SMN2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL2848982 | 0.74 | HTT (0.48) | HTTSMN1; SMN2CYP1A2ALDH1A1KDM4E | |
| SCHEMBL22023523 | 0.73 | HTT (0.54) | HTTSMN1; SMN2CYP1A2ALDH1A1KDM4E | |
| SCHEMBL16523438 | 0.73 | SMN1; SMN2 (1.00) | HTTSMN1; SMN2CYP1A2ALDH1A1KDM4E | |
| SCHEMBL30231342 | 0.72 | ACKR3 (0.69) | HTTSMN1; SMN2CYP1A2ALDH1A1KDM4E | |
| SCHEMBL24163465 | 0.71 | HTT (0.48) | HTTSMN1; SMN2CYP1A2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |