Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | PNP | P00491 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | GMNN | O75496 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8441987 | 0.80 | P4HB (0.37) | P4HBTSHRPNPEPHX2BACE1 | |
| SCHEMBL8444633 | 0.79 | P4HB (0.43) | P4HBTSHRGABRA1GABRB2PNP | |
| SCHEMBL8444638 | 0.79 | EPHX2 (0.38) | P4HBTSHRPNPEPHX2BACE1 | |
| SCHEMBL8443411 | 0.76 | EPHX2 (0.42) | P4HBTSHREPHX2RAB9ANPC1 | |
| SCHEMBL20067971 | 0.76 | P4HB (0.46) | P4HBTSHRGABRA1GABRB2EPHX2 | |
| SCHEMBL8443558 | 0.76 | P4HB (0.39) | P4HBTSHRGABRA1GABRB2PNP | |
| SCHEMBL8444001 | 0.71 | CA2 (0.38) | CA2LMNACYP3A4MAPTHPGD | |
| SCHEMBL8443614 | 0.71 | ALDH1A1 (0.36) | P4HBTSHRPNPEPHX2BACE1 | |
| SCHEMBL11855729 | 0.71 | P4HB (0.45) | P4HBTSHRGABRA1GABRB2EPHX2 | |
| SCHEMBL8441756 | 0.70 | MAPT (0.38) | P4HBTSHRPNPEPHX2BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962435-A | ANTICHOLESTEROL AGENT | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-05 | — | — | US | disclosed |
| US-5677291-A | Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols | HOECHST MARION ROUSSEL, INC. (US) | 1997-10-14 | — | — | US | disclosed |