Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.48 |
| ▸ | PDE5A | O76074 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 7/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.47 |
| ▸ | PDE9A | O76083 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7028354 | 0.91 | KMT2A (0.60) | ALDH1A1KMT2AKDM4EPOLBRAD52 | |
| SCHEMBL7418635 | 0.89 | POLB (0.51) | ALDH1A1KMT2AKDM4EL3MBTL1POLB | |
| SCHEMBL7423097 | 0.83 | POLB (0.48) | KMT2APOLBRAD52PDE5APDE9A | |
| SCHEMBL7420540 | 0.83 | POLB (0.50) | KMT2APOLBRAD52PDE5APDE9A | |
| SCHEMBL7420650 | 0.82 | PDE5A (0.50) | ALDH1A1KMT2AKDM4EPOLBRAD52 | |
| SCHEMBL13692589 | 0.82 | KMT2A (0.73) | ALDH1A1KMT2AKDM4EGAAL3MBTL1 | |
| SCHEMBL7425050 | 0.81 | ALDH1A1 (0.47) | ALDH1A1KMT2AKDM4EGAAPOLB | |
| SCHEMBL7416586 | 0.81 | EGFR (0.52) | ALDH1A1KMT2AGAAPOLBRAD52 | |
| SCHEMBL7418464 | 0.81 | APP (0.53) | ALDH1A1KMT2AGAAPOLBRAD52 | |
| SCHEMBL7418050 | 0.81 | BCHE (0.50) | ALDH1A1KMT2AKDM4EGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6008226-A | AN ENZYME INHIBITOR OF C-GMP-PHOSPHODIESTERASE FOR TREATING HEART FAILURE, HYPERTENSION, REVERSING OR REDUCING NITRATE-INDUCED TOLERANCE AND ANGINA PECTORIS, CONGESTIVE HEART DISEASE AND MYOCARDIAL INFARCTION | SANOFI-SYNTHELABO (FR) | 1999-12-28 | — | — | US | disclosed |