Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RAD52 | P43351 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE5A | O76074 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | PDE9A | O76083 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7028354 | 0.92 | KMT2A (0.60) | POLBRAD52KMT2APDE4BBCHE | |
| SCHEMBL7422618 | 0.90 | POLB (0.46) | POLBRAD52KMT2APDE4BPDE5A | |
| SCHEMBL7423097 | 0.89 | POLB (0.48) | POLBRAD52KMT2APDE4BPDE5A | |
| SCHEMBL7420650 | 0.88 | PDE5A (0.50) | POLBRAD52KMT2APDE4BPDE5A | |
| SCHEMBL7418635 | 0.87 | POLB (0.51) | POLBRAD52KMT2APDE4BPDE5A | |
| SCHEMBL7416586 | 0.87 | EGFR (0.52) | POLBRAD52KMT2APDE5APDE9A | |
| Hydrochloric Acid SCHEMBL7423114 | 0.86 | EGFR (0.51) | POLBRAD52KMT2APDE5APDE9A | |
| SCHEMBL8444030 | 0.83 | ALDH1A1 (0.50) | POLBRAD52KMT2APDE5APDE9A | |
| SCHEMBL7422887 | 0.82 | ACHE (0.57) | POLBRAD52KMT2APDE5ABCHE | |
| SCHEMBL7419604 | 0.81 | ACHE (0.53) | POLBRAD52KMT2APDE4BPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6008226-A | AN ENZYME INHIBITOR OF C-GMP-PHOSPHODIESTERASE FOR TREATING HEART FAILURE, HYPERTENSION, REVERSING OR REDUCING NITRATE-INDUCED TOLERANCE AND ANGINA PECTORIS, CONGESTIVE HEART DISEASE AND MYOCARDIAL INFARCTION | SANOFI-SYNTHELABO (FR) | 1999-12-28 | — | — | US | disclosed |
| US-5852035-A | Method for inhibiting neoplastic cells and related conditions by exposure to substituted N- arylmethyl and heterocyclmethyl-1H-pyrazolo (3,4-B) quinolin-4-amines | CELL PATHWAYS, INC. (US) | 1998-12-22 | — | — | US | disclosed |
| US-5843956-A | Substituted N-arylmethyl and heterocyclylmethyl-1H-pyrazolo (3,4-b) quinolin-4-amines and compositions and methods of use thereof | SANOFI (FR) | 1998-12-01 | — | — | US | disclosed |
| US-5614530-A | GMP PHOSPHODIESTERASE INHIBITOR, HYPOTENSIVE | STERLING WINTHROP INC. (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1996028159-A1 | SUBSTITUTED N-ARYLMETHYL AND HETEROCYCLYLMETHYL-1H-PYRAZOLO[3,4-b]QUINOLIN-4-AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1996-09-19 | — | — | WO | disclosed |