Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | APP | P05067 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | NCF1 | P14598 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | ACP1 | P24666 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.46 |
| ▸ | PDE9A | O76083 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7423114 | 0.99 | EGFR (0.51) | EGFRAPPLMNASMN1; SMN2TP53 | |
| SCHEMBL7028354 | 0.90 | KMT2A (0.60) | APPLMNASMN1; SMN2MAPTPOLB | |
| SCHEMBL7421877 | 0.89 | TACR3 (0.51) | EGFRLMNASMN1; SMN2TP53MAPT | |
| SCHEMBL7424176 | 0.89 | MEN1 (0.51) | EGFRLMNASMN1; SMN2TP53MAPT | |
| SCHEMBL7418464 | 0.89 | APP (0.53) | APPLMNASMN1; SMN2TP53MAPT | |
| SCHEMBL7420540 | 0.87 | POLB (0.50) | POLBRAD52KMT2AABL1SRC | |
| SCHEMBL7422887 | 0.86 | ACHE (0.57) | APPSMN1; SMN2MAPTTHRBPOLB | |
| SCHEMBL7420650 | 0.86 | PDE5A (0.50) | LMNASMN1; SMN2MAPTPOLBRAD52 | |
| SCHEMBL7418635 | 0.85 | POLB (0.51) | MAPTPOLBRAD52KMT2AABL1 | |
| SCHEMBL8444030 | 0.81 | ALDH1A1 (0.50) | EGFRLMNASMN1; SMN2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6008226-A | AN ENZYME INHIBITOR OF C-GMP-PHOSPHODIESTERASE FOR TREATING HEART FAILURE, HYPERTENSION, REVERSING OR REDUCING NITRATE-INDUCED TOLERANCE AND ANGINA PECTORIS, CONGESTIVE HEART DISEASE AND MYOCARDIAL INFARCTION | SANOFI-SYNTHELABO (FR) | 1999-12-28 | — | — | US | disclosed |
| US-5852035-A | Method for inhibiting neoplastic cells and related conditions by exposure to substituted N- arylmethyl and heterocyclmethyl-1H-pyrazolo (3,4-B) quinolin-4-amines | CELL PATHWAYS, INC. (US) | 1998-12-22 | — | — | US | disclosed |
| US-5843956-A | Substituted N-arylmethyl and heterocyclylmethyl-1H-pyrazolo (3,4-b) quinolin-4-amines and compositions and methods of use thereof | SANOFI (FR) | 1998-12-01 | — | — | US | disclosed |
| EP-0813410-A4 | SUBSTITUTED N-ARYLMETHYL AND HETEROCYCLYLMETHYL-1H-PYRAZOLO 3,4-b]QUINOLIN-4-AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF | SANOFI WINTHROP INC (US) | 1998-08-19 | — | — | EP | disclosed |
| EP-0813410-A1 | SUBSTITUTED N-ARYLMETHYL AND HETEROCYCLYLMETHYL-1H-PYRAZOLO 3,4-b]QUINOLIN-4-AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1997-12-29 | — | — | EP | disclosed |
| US-5614530-A | GMP PHOSPHODIESTERASE INHIBITOR, HYPOTENSIVE | STERLING WINTHROP INC. (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1996028159-A1 | SUBSTITUTED N-ARYLMETHYL AND HETEROCYCLYLMETHYL-1H-PYRAZOLO[3,4-b]QUINOLIN-4-AMINES AND COMPOSITIONS AND METHODS OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1996-09-19 | — | — | WO | disclosed |