Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2473268 | 0.89 | NPC1 (0.44) | LMNAMAPTGAASMN1; SMN2MAPK1 | |
| SCHEMBL13372654 | 0.86 | HSP90AA1 (0.40) | LMNAMAPTGAASMN1; SMN2MAPK1 | |
| SCHEMBL2478976 | 0.86 | HSP90AA1 (0.40) | LMNAMAPTGAASMN1; SMN2MAPK1 | |
| SCHEMBL2475172 | 0.86 | HSP90AA1 (0.40) | LMNAMAPTGAASMN1; SMN2MAPK1 | |
| SCHEMBL8444087 | 0.81 | LMNA (0.38) | LMNAMAPTGAASMN1; SMN2MAPK1 | |
| SCHEMBL2472272 | 0.81 | PDE10A (0.43) | LMNAMAPTGAASMN1; SMN2MAPK1 | |
| SCHEMBL2472998 | 0.78 | ALDH1A1 (0.45) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2805108 | 0.70 | RAB9A (0.43) | LMNAMAPTGAASMN1; SMN2MAPK1 | |
| SCHEMBL2479017 | 0.69 | NPC1 (0.40) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL2471610 | 0.68 | NFKBIA (0.40) | LMNAMAPTSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010066832-A1 | TRIPLE SUBSTITUTED PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES OR CONDITIONS, OR CANCER | NOSCIRA, S.A. (ES) | 2010-06-17 | — | — | WO | disclosed |
| EP-2196466-A1 | Triple substituted phenanthroline derivatives for the treatment of neurodegenerative or heamatological diseases or conditions | NOSCIRA, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |