Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8444952 | 0.88 | LMNA (0.37) | NPC1RAB9APOLBCREBBPTDP1 | |
| SCHEMBL8445329 | 0.88 | NPC1 (0.38) | NPC1RAB9APOLBCREBBPPTGDR2 | |
| SCHEMBL8445321 | 0.87 | CREBBP (0.36) | NPC1RAB9ACREBBPTDP1ALDH1A1 | |
| SCHEMBL8443151 | 0.84 | ALDH1A1 (0.41) | NPC1RAB9APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL8442125 | 0.84 | CREBBP (0.38) | POLBCREBBPTDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8441685 | 0.82 | EDNRA (0.46) | ALDH1A1SMN1; SMN2KMT2ALMNAEDNRA | |
| SCHEMBL8445360 | 0.79 | ALDH1A1 (0.42) | NPC1TDP1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL8443878 | 0.78 | EDNRA (0.36) | NPC1RAB9AEDNRA | |
| SCHEMBL8441255 | 0.77 | EDNRA (0.40) | ALDH1A1SMN1; SMN2KMT2ALMNAEDNRA | |
| SCHEMBL7569402 | 0.76 | HPGD (0.39) | NPC1RAB9APOLBALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962682-A | Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists | HOFFMANN-LA ROCHE INC. (US) | 1999-10-05 | — | — | US | disclosed |