Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.56 |
| ▸ | CNR2 | P34972 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPD | P32754 | 9/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845150 | 0.89 | CNR1 (0.64) | CNR1CNR2ALDH1A1TSHRDHODH | |
| SCHEMBL844509 | 0.82 | CNR1 (0.58) | CNR1CNR2ALDH1A1L3MBTL1LMNA | |
| SCHEMBL18673206 | 0.81 | CNR1 (0.78) | CNR1CNR2ALDH1A1L3MBTL1DHODH | |
| SCHEMBL17694537 | 0.81 | CNR1 (0.67) | CNR1CNR2ALDH1A1DHODH | |
| SCHEMBL844571 | 0.78 | CNR1 (0.79) | CNR1CNR2ALDH1A1L3MBTL1LMNA | |
| SCHEMBL844516 | 0.76 | CNR1 (0.75) | CNR1CNR2ALDH1A1LMNATSHR | |
| Hydrochloric Acid SCHEMBL844735 | 0.74 | CNR1 (0.86) | CNR1CNR2ALDH1A1LMNATSHR | |
| SCHEMBL6681525 | 0.74 | CNR1 (0.65) | CNR1CNR2ALDH1A1LMNATSHR | |
| SCHEMBL844485 | 0.73 | CNR1 (0.75) | CNR1CNR2ALDH1A1LMNATSHR | |
| SCHEMBL17692331 | 0.73 | CNR1 (0.90) | CNR1CNR2ALDH1A1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552015-B2 | Quinazolinone derivatives and their use as CB agonists | NOVARTIS AG (CH) | 2013-10-08 | — | — | US | disclosed |
| EP-1472234-B1 | QUINAZOLINONE DERIVATIVES AND THEIR USE AS CB AGONISTS | NOVARTIS AG (CH) | 2012-03-28 | — | — | EP | disclosed |
| EP-2319839-A1 | Quinazolinone derivatives and their use as CB agonists | Novartis AG (CH) | 2011-05-11 | — | — | EP | disclosed |
| US-20070265285-A1 | Quinazolinone derivatives and their use as CB agonists | NOVARTIS AG (CH) | 2007-11-15 | — | — | US | disclosed |
| US-20050085493-A1 | Quinazolinone derivatives and their use as cb agonists | BRAIN CHRISTOPHER T (GB) | 2005-04-21 | — | — | US | disclosed |
| EP-1472234-A1 | QUINAZOLINONE DERIVATIVES AND THEIR USE AS CB AGONISTS | Novartis AG (CH) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003066603-A1 | QUINAZOLINONE DERIVATIVES AND THEIR USE AS CB AGONISTS | NOVARTIS AG (CH) | 2003-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265285-A1 | Quinazolinone derivatives and their use as CB agonists | CNR1, ADRB1, ADRA1D | CNR1 1/4885CNR2 8/4885ALDH1A1 680/4885 |
| US-20050085493-A1 | Quinazolinone derivatives and their use as cb agonists | CNR1, ADRB1, ADRA2B | CNR1 1/4885CNR2 8/4885ALDH1A1 718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.