Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8447191 | 0.87 | CYP1A2 (0.54) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL8522550 | 0.84 | CNR1 (0.49) | TSHRNPC1CNR1ACHECNR2 | |
| SCHEMBL8449970 | 0.81 | CYP1A2 (0.49) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL8445591 | 0.80 | CYP2D6 (0.50) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL8443181 | 0.78 | CCR2 (0.47) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| Cyclopropane SCHEMBL8448561 | 0.76 | NPSR1 (0.52) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL8624570 | 0.75 | NPSR1 (0.47) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL19128354 | 0.75 | CYP1A2 (0.65) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL8624571 | 0.74 | NPSR1 (0.45) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR | |
| SCHEMBL1045876 | 0.72 | CYP1A2 (0.62) | CYP1A2CYP3A4CYP2D6CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776932-A | ANTIALLERGENS, ANTIASTHMATICS, ANTIINFLAMMATORY AGENTS AND MODULATORS | ARZNEIMITTELWERK DRESDEN G.M.B.H. (DE) | 1998-07-07 | — | — | US | claimed |
| EP-0888307-A1 | 1,3,5-TRISUBSTITUTED INDAZOLE DERIVATIVES WITH AN ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING ACTION | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1999-01-07 | — | — | EP | disclosed |
| US-5776932-A | ANTIALLERGENS, ANTIASTHMATICS, ANTIINFLAMMATORY AGENTS AND MODULATORS | ARZNEIMITTELWERK DRESDEN G.M.B.H. (DE) | 1998-07-07 | — | — | US | disclosed |
| WO-1997034874-A1 | 1,3,5-TRISUBSTITUTED INDAZOLE DERIVATIVES WITH AN ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING ACTION | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1997-09-25 | — | — | WO | disclosed |