SCHEMBL8447191

SCHEMBL8447191

Oc1ccc2c(c1)c(O)nn2Cc1ccc(Cl)cc1Cl

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.54
CYP3A4 P08684 2/20 0.54
CYP2C9 P11712 2/20 0.54
CYP2D6 P10635 1/20 0.54
TSHR P16473 1/20 0.54
PMP22 Q01453 1/20 0.54
HIF1A Q16665 1/20 0.54
NPSR1 Q6W5P4 1/20 0.54
SLC9A1 P19634 1/20 0.45
LMNA P02545 4/20 0.44
ALDH1A1 P00352 3/20 0.44
HTT P42858 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
JAK2 O60674 1/20 0.44
TP53 P04637 1/20 0.44
RAB9A P51151 1/20 0.44
NPC1 O15118 1/20 0.43
POLB P06746 1/20 0.41
SLC16A3 O15427 2/20 0.41
SLC16A1 P53985 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8445913 0.87 CYP1A2 (0.52) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL8449970 0.84 CYP1A2 (0.49) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL8446930 0.83 MCL1 (0.42) CYP1A2CYP3A4CYP2C9CYP2D6NPSR1
SCHEMBL8445591 0.82 CYP2D6 (0.50) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
Cyclopropane SCHEMBL8448561 0.78 NPSR1 (0.52) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL8624570 0.77 NPSR1 (0.47) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL8307879 0.77 ABCB11 (0.47) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL8627901 0.74 RAB9A (0.50) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL8624571 0.74 NPSR1 (0.45) CYP1A2CYP3A4CYP2C9CYP2D6TSHR
SCHEMBL8042523 0.73 NPSR1 (0.51) CYP1A2CYP3A4CYP2C9CYP2D6TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888307-A1 1,3,5-TRISUBSTITUTED INDAZOLE DERIVATIVES WITH AN ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING ACTION ARZNEIMITTELWERK DRESDEN GMBH (DE) 1999-01-07 EP claimed
US-5776932-A ANTIALLERGENS, ANTIASTHMATICS, ANTIINFLAMMATORY AGENTS AND MODULATORS ARZNEIMITTELWERK DRESDEN G.M.B.H. (DE) 1998-07-07 US claimed
WO-1997034874-A1 1,3,5-TRISUBSTITUTED INDAZOLE DERIVATIVES WITH AN ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING ACTION ARZNEIMITTELWERK DRESDEN GMBH (DE) 1997-09-25 WO claimed
EP-0888307-A1 1,3,5-TRISUBSTITUTED INDAZOLE DERIVATIVES WITH AN ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING ACTION ARZNEIMITTELWERK DRESDEN GMBH (DE) 1999-01-07 EP disclosed
US-5776932-A ANTIALLERGENS, ANTIASTHMATICS, ANTIINFLAMMATORY AGENTS AND MODULATORS ARZNEIMITTELWERK DRESDEN G.M.B.H. (DE) 1998-07-07 US disclosed
WO-1997034874-A1 1,3,5-TRISUBSTITUTED INDAZOLE DERIVATIVES WITH AN ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING ACTION ARZNEIMITTELWERK DRESDEN GMBH (DE) 1997-09-25 WO disclosed