Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A9 | P06702 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 5/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1348511 | 0.83 | S100A9 (0.44) | S100A9EGFRKDM1AMAOAALDH1A1 | |
| SCHEMBL1771843 | 0.80 | S100A9 (0.49) | S100A9PIK3CDPIK3CGEGFRKDM1A | |
| SCHEMBL11687798 | 0.80 | ALDH1A1 (0.44) | ALDH1A1KMT2AGFERLMNAMMP1 | |
| SCHEMBL25820334 | 0.79 | PIK3CD (0.44) | PIK3CDPIK3CGPIK3CAALDH1A1MEN1 | |
| SCHEMBL15052712 | 0.77 | S100A9 (0.39) | S100A9EGFRKDM1AMAOAALDH1A1 | |
| SCHEMBL2372109 | 0.77 | S100A9 (0.49) | S100A9EGFRKDM1AMAOAALDH1A1 | |
| SCHEMBL3346180 | 0.76 | SMN1; SMN2 (0.59) | S100A9EGFRKDM1AMAOAALDH1A1 | |
| SCHEMBL1348246 | 0.76 | ALDH1A1 (0.51) | S100A9PIK3CDPIK3CGPIK3CAEGFR | |
| SCHEMBL578845 | 0.76 | PIK3CD (0.43) | PIK3CDPIK3CGPIK3CAALDH1A1MEN1 | |
| SCHEMBL4637538 | 0.76 | PIK3CD (0.44) | PIK3CDPIK3CGPIK3CAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367830-B2 | Methods for the identification of phosphatidylinositol kinase interacting molecules and for the purification of phosphatidylinositol kinase proteins | CELLZOME AG (DE) | 2013-02-05 | — | — | US | disclosed |
| US-8367830-B2 | Methods for the identification of phosphatidylinositol kinase interacting molecules and for the purification of phosphatidylinositol kinase proteins | CELLZOME AG (DE) | 2013-02-05 | — | — | US | disclosed |
| US-8367830-B2 | Methods for the identification of phosphatidylinositol kinase interacting molecules and for the purification of phosphatidylinositol kinase proteins | CELLZOME AG (DE) | 2013-02-05 | — | — | US | disclosed |
| US-20120135421-A1 | METHODS FOR THE IDENTIFICATION OF PHOSPHATIDYLINOSITOL KINASE INTERACTING MOLECULES AND FOR THE PURIFICATION OF PHOSPHATIDYLINOSITOL KINASE PROTEINS | CELLZOME AG (DE) | 2012-05-31 | — | — | US | disclosed |
| US-20120135421-A1 | METHODS FOR THE IDENTIFICATION OF PHOSPHATIDYLINOSITOL KINASE INTERACTING MOLECULES AND FOR THE PURIFICATION OF PHOSPHATIDYLINOSITOL KINASE PROTEINS | CELLZOME AG (DE) | 2012-05-31 | — | — | US | disclosed |
| US-20120135421-A1 | METHODS FOR THE IDENTIFICATION OF PHOSPHATIDYLINOSITOL KINASE INTERACTING MOLECULES AND FOR THE PURIFICATION OF PHOSPHATIDYLINOSITOL KINASE PROTEINS | CELLZOME AG (DE) | 2012-05-31 | — | — | US | disclosed |
| EP-2432782-A1 | METHODS FOR THE IDENTIFICATION OF PHOSPHATIDYLINOSITOL KINASE INTERACTING MOLECULES AND FOR THE PURIFICATION OF PHOSPHATIDYLINOSITOL KINASE PROTEINS | CELLZOME AG (DE) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010133318-A1 | METHODS FOR THE IDENTIFICATION OF PHOSPHATIDYLINOSITOL KINASE INTERACTING MOLECULES AND FOR THE PURIFICATION OF PHOSPHATIDYLINOSITOL KINASE PROTEINS | CELLZOME AG (DE) | 2010-11-25 | — | — | WO | disclosed |
| WO-2010092015-A1 | UREA TRIAZOLOLO [1, 5-A] PYRIDINE DERIVATIVES AS PI3K INHIBITORS | CELLZOME LIMITED (GB) | 2010-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135421-A1 | METHODS FOR THE IDENTIFICATION OF PHOSPHATIDYLINOSITOL KINASE INTERACTING MOLECULES AND FOR THE PURIFICATION OF PHOSPHATIDYLINOSITOL KINASE PROTEINS | PIP4K2B, PIP4K2C, PI4KB | S100A9 4244/4885PIK3CD 17/4885PIK3CG 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.