SCHEMBL1348246

SCHEMBL1348246

CC(C)(C)NS(=O)(=O)c1cncc(Br)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.51
PIK3C3 Q8NEB9 1/20 0.46
S100A9 P06702 1/20 0.46
MAPT P10636 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
KDM4E B2RXH2 1/20 0.45
MEN1 O00255 1/20 0.45
NPC1 O15118 1/20 0.45
LMNA P02545 1/20 0.45
HPGD P15428 1/20 0.45
RAB9A P51151 1/20 0.45
KMT2A Q03164 1/20 0.45
PIK3CG P48736 6/20 0.44
PIK3CD O00329 5/20 0.44
PIK3CB P42338 4/20 0.44
PIK3CA P42336 2/20 0.44
PAK4 O96013 1/20 0.44
JAK1 P23458 1/20 0.44
CSNK1A1 P48729 1/20 0.44
AAK1 Q2M2I8 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1348319 0.83 KDM4E (0.46) ALDH1A1PIK3C3S100A9SMN1; SMN2KDM4E
SCHEMBL1348659 0.83 S100A9 (0.44) ALDH1A1PIK3C3S100A9SMN1; SMN2KDM4E
SCHEMBL24549324 0.81 ALDH1A1 (0.53) ALDH1A1PIK3C3MAPTSMN1; SMN2KDM4E
SCHEMBL1771843 0.80 S100A9 (0.49) S100A9SMN1; SMN2LMNAPIK3CGPIK3CD
SCHEMBL2922267 0.77 ALDH1A1 (0.49) ALDH1A1PIK3C3MAPTSMN1; SMN2KDM4E
SCHEMBL2372109 0.77 S100A9 (0.49) ALDH1A1S100A9SMN1; SMN2KDM4EMEN1
SCHEMBL30744218 0.77 PIK3CD (0.41) ALDH1A1S100A9SMN1; SMN2KDM4ENPC1
SCHEMBL3346180 0.76 SMN1; SMN2 (0.59) ALDH1A1S100A9SMN1; SMN2KDM4EEGFR
SCHEMBL844606 0.76 S100A9 (0.46) ALDH1A1S100A9MAPTSMN1; SMN2MEN1
SCHEMBL12189183 0.76 ALDH1A1 (0.48) ALDH1A1PIK3C3MAPTSMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250230144-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2025-07-17 US disclosed
US-20230322726-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2023-10-12 US disclosed
US-20230322726-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2023-10-12 US disclosed
US-20230322726-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2023-10-12 US disclosed
US-20220324836-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2022-10-13 US disclosed
EP-3575288-B1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2021-10-27 EP disclosed
EP-3575288-B1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2021-10-27 EP disclosed
US-11008306-B2 Quinazolines as potassium ion channel inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2021-05-18 US disclosed
US-11008306-B2 Quinazolines as potassium ion channel inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2021-05-18 US disclosed
US-20200255407-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2020-08-13 US disclosed
WO-2010057877-A1 7-PYRIDINYL- OR PHENYL- SUBSTITUTED TRIAZOLO [1, 5 -A] PYRIDINES AS PI3K INHIBITORS CELLZOME LIMITED (GB) 2010-05-27 WO disclosed
US-7718661-B2 Acetylenyl-pyrazolo-pyrimidine derivatives HOFFMANN-LA ROCHE INC. (US) 2010-05-18 US disclosed
EP-1863818-B1 ACETYLENYL-PYRAZOLO-PVRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS HOFFMANN LA ROCHE (CH) 2010-03-10 EP disclosed
US-20080300250-A1 ACETYLENYL-PYRAZOLO-PYRIMIDINE DERIVATIVES GATTI MCARTHUR SILVIA 2008-12-04 US disclosed
US-7446113-B2 Acetylenyl-pyrazolo-pyrimidine derivatives HOFFMAN-LA ROCHE INC. (US) 2008-11-04 US disclosed
EP-1863818-A1 ACETYLENYL-PYRAZOLO-PVRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS F.HOFFMANN-LA ROCHE AG (CH) 2007-12-12 EP disclosed
US-20070167460-A1 Acetylenyl-pyrazolo-pyrimidine derivatives MCARTHUR SILVIA G 2007-07-19 US disclosed
US-7238808-B2 Acetylenyl-pyrazolo-pyrimidine derivatives HOFFMANN-LA ROCHE INC. (US) 2007-07-03 US disclosed
US-20060217387-A1 Acetylenyl-pyrazolo-pyrimidine derivatives F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) 2006-09-28 US disclosed
WO-2006099972-A1 ACETYLENYL-PYRAZOLO-PVRIMIDINE DERIVATIVES AS MGLUR2 ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2006-09-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220324836-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS KCNJ4, KCNK4, KCNQ4 ALDH1A1 2513/4885PIK3C3 2490/4885S100A9 4010/4885
US-20250230144-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS KCNJ4, KCNK4, KCNQ4 ALDH1A1 2513/4885PIK3C3 2490/4885S100A9 4010/4885
US-20200255407-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS KCNJ4, KCNK4, KCNQ4 ALDH1A1 2513/4885PIK3C3 2490/4885S100A9 4010/4885
US-20080300250-A1 ACETYLENYL-PYRAZOLO-PYRIMIDINE DERIVATIVES NAT1, TPMT, ACAT1 ALDH1A1 90/4885PIK3C3 3880/4885S100A9 3738/4885
US-20060217387-A1 Acetylenyl-pyrazolo-pyrimidine derivatives NAT1, TPMT, ACAT1 ALDH1A1 90/4885PIK3C3 3880/4885S100A9 3738/4885
US-20070167460-A1 Acetylenyl-pyrazolo-pyrimidine derivatives NAT1, ADORA2B, TPMT ALDH1A1 67/4885PIK3C3 4195/4885S100A9 3984/4885
US-11008306-B2 Quinazolines as potassium ion channel inhibitors KCNJ4, KCNK4, KCNQ4 ALDH1A1 2513/4885PIK3C3 2490/4885S100A9 4010/4885
US-20230322726-A1 QUINAZOLINES AS POTASSIUM ION CHANNEL INHIBITORS KCNJ4, KCNK4, KCNQ4 ALDH1A1 2513/4885PIK3C3 2490/4885S100A9 4010/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.