Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.43 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8446157 | 0.85 | SLC9A1 (0.60) | SLC9A1SLC9A3SLC9A2 | |
| SCHEMBL8447166 | 0.85 | SLC9A1 (0.47) | SLC9A1SLC9A3SLC9A2 | |
| SCHEMBL8446518 | 0.85 | SLC9A1 (0.46) | SLC9A1SLC9A3SLC9A2 | |
| SCHEMBL8699860 | 0.84 | ALDH1A1 (0.52) | ALDH1A1HTTMEN1KMT2AGAA | |
| SCHEMBL8444821 | 0.83 | NEK2 (0.47) | SLC9A1SLC9A3SLC9A2 | |
| SCHEMBL8444829 | 0.82 | SLC9A1 (0.44) | SLC9A1SLC9A3SLC9A2 | |
| SCHEMBL8446517 | 0.82 | SLC9A1 (0.44) | SLC9A1SLC9A3SLC9A2 | |
| SCHEMBL8444812 | 0.82 | SLC9A1 (0.44) | SLC9A1SLC9A3SLC9A2 | |
| SCHEMBL8444311 | 0.82 | SLC9A1 (0.44) | SLC9A1SLC9A3SLC9A2 | |
| SCHEMBL8446257 | 0.82 | SLC9A1 (0.44) | SLC9A1SLC9A3SLC9A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699666-B1 | Heterocyclic substituted benzoylguanidine | MERCK PATENT GMBH (DE) | 1999-01-07 | — | — | EP | disclosed |
| US-5753680-A | Heterocyclyl-benzoylguanidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-05-19 | — | — | US | disclosed |
| EP-0699666-A1 | Heterocyclic substituted benzoylguanidine | MERCK PATENT GmbH (DE) | 1996-03-06 | — | — | EP | disclosed |