SCHEMBL8446629

SCHEMBL8446629

C=Cc1ccc(OCc2ccc(COc3ccc(C(C)Cl)cc3)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXRA P19793 1/20 0.46
RXRB P28702 1/20 0.46
FFAR1 O14842 2/20 0.45
NPC1 O15118 1/20 0.43
CASP3 P42574 1/20 0.43
RAB9A P51151 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
SENP8 Q96LD8 1/20 0.43
SENP7 Q9BQF6 1/20 0.43
SENP6 Q9GZR1 1/20 0.43
CHRNB2 P17787 1/20 0.42
CHRNB4 P30926 1/20 0.42
CHRNA3 P32297 1/20 0.42
CHRNA7 P36544 1/20 0.42
CHRNA4 P43681 1/20 0.42
APP P05067 5/20 0.41
PTPN2 P17706 1/20 0.40
PTPN1 P18031 1/20 0.40
PTPN11 Q06124 1/20 0.40
HRH3 Q9Y5N1 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6743494 0.88 RXRA (0.49) RXRARXRBFFAR1NPC1CASP3
SCHEMBL6390372 0.85 FFAR1 (0.45) RXRARXRBFFAR1NPC1CASP3
SCHEMBL6391318 0.85 FFAR1 (0.45) RXRARXRBFFAR1NPC1CASP3
SCHEMBL16117356 0.85 NPC1 (0.50) RXRARXRBFFAR1NPC1CASP3
SCHEMBL16117358 0.85 NPC1 (0.50) RXRARXRBFFAR1NPC1CASP3
SCHEMBL13242652 0.85 APP (0.54) NPC1CASP3RAB9ASMN1; SMN2SENP8
SCHEMBL6388039 0.85 APP (0.54) NPC1CASP3RAB9ASMN1; SMN2SENP8
SCHEMBL16022462 0.82 RXRA (0.47) RXRARXRBFFAR1NPC1CASP3
SCHEMBL8830853 0.81 MAPT (0.43) RXRARXRBFFAR1NPC1RAB9A
SCHEMBL810409 0.81 ALDH1A1 (0.52) NPC1RAB9ASMN1; SMN2CHRNB2CHRNB4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5663260-A Hyperbranched copolymers from AB monomers and C monomers CORNELL RESEARCH FOUNDATION, INC. (US) 1997-09-02 US claimed
US-5587441-A Hyperbranched polymers from AB monomers CORNELL RESEARCH FOUNDATION, INC. (US) 1996-12-24 US claimed
US-5587446-A Hyperbranched polymers from AB monomers CORNELL RESEARCH FOUNDATION, INC. (US) 1996-12-24 US claimed
EP-0545201-B2 Durable water repellent glass surface PPG IND OHIO INC (US) 2012-08-22 EP disclosed
EP-0545201-B1 Durable water repellent glass surface PPG IND OHIO INC (US) 1999-10-27 EP disclosed
EP-0791021-B1 HYPERBRANCHED POLYMERS FROM AB MONOMERS CORNELL RES FOUNDATION INC (US) 1999-01-07 EP disclosed
US-5663260-A Hyperbranched copolymers from AB monomers and C monomers CORNELL RESEARCH FOUNDATION, INC. (US) 1997-09-02 US disclosed
EP-0791021-A1 HYPERBRANCHED POLYMERS FROM AB MONOMERS CORNELL RESEARCH FOUNDATION, INC. (US) 1997-08-27 EP disclosed
US-5587441-A Hyperbranched polymers from AB monomers CORNELL RESEARCH FOUNDATION, INC. (US) 1996-12-24 US disclosed
US-5587446-A Hyperbranched polymers from AB monomers CORNELL RESEARCH FOUNDATION, INC. (US) 1996-12-24 US disclosed
WO-1996014346-A1 HYPERBRANCHED POLYMERS FROM AB MONOMERS CORNELL RESEARCH FOUNDATION, INC. (US) 1996-05-17 WO disclosed
EP-0477805-B1 Water repellent surface treatment PPG INDUSTRIES INC (US) 1995-11-15 EP disclosed
US-5308705-A Perfluoroalkyl alkyl silane and olefin telomer, for metals, plastics, ceramics, enamels, automobile panels PPG INDUSTRIES, INC. (US) 1994-05-03 US disclosed
EP-0545201-A2 Durable water repellent glass surface PPG INDUSTRIES, INC. (US) 1993-06-09 EP disclosed
EP-0477805-A1 Water repellent surface treatment PPG INDUSTRIES, INC. (US) 1992-04-01 EP disclosed
EP-0452723-A1 Chemically treated glass surface PPG INDUSTRIES, INC. (US) 1991-10-23 EP disclosed
US-4997684-A Method of using perfluoroalkylsilanes to lower the surface energy of glass PPG INDUSTRIES, INC. (US) 1991-03-05 US disclosed
US-4983459-A Chemically reacted glass surface PPG INDUSTRIES, INC. (US) 1991-01-08 US disclosed