SCHEMBL8446867

SCHEMBL8446867

CNc1nc(OC)cc(Cl)c1N

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PGK1 P00558 4/20 0.41
ALDH1A1 P00352 3/20 0.34
KDM4E B2RXH2 1/20 0.34
LRRK2 Q5S007 4/20 0.33
NPC1 O15118 2/20 0.33
NQO2 P16083 1/20 0.33
RAB9A P51151 1/20 0.33
CYP1A2 P05177 1/20 0.33
GAA P10253 1/20 0.32
MAT2A P31153 1/20 0.32
HSP90AA1 P07900 1/20 0.32
HSP90AB1 P08238 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20429871 0.77 ALDH1A1 (0.36) PGK1ALDH1A1LRRK2NPC1NQO2
SCHEMBL22833435 0.76 TDO2 (0.39) ALDH1A1KDM4ENPC1RAB9AGAA
SCHEMBL30294903 0.76 TDO2 (0.39) ALDH1A1KDM4ENPC1RAB9AGAA
SCHEMBL28324862 0.76 POLB (0.42) ALDH1A1KDM4ENPC1RAB9AGAA
SCHEMBL30185761 0.74 ALDH1A1 (0.33) PGK1ALDH1A1NPC1RAB9AGAA
SCHEMBL7885119 0.74 ALDH1A1 (0.33) PGK1ALDH1A1NPC1RAB9AGAA
SCHEMBL23457188 0.70 PGK1 (0.33) PGK1ALDH1A1
SCHEMBL2286692 0.69 PDE2A (0.34) ALDH1A1KDM4ECYP1A2GAAHSP90AA1
SCHEMBL26684117 0.69 POLB (0.44) ALDH1A1KDM4ENQO2CYP1A2GAA
SCHEMBL29378197 0.68 SIRT2 (0.41) PGK1ALDH1A1KDM4ENPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0791352-B1 Hair dyeing composition GOLDWELL GMBH (DE) 1999-09-08 EP disclosed
EP-0791352-A2 Hair dyeing composition GOLDWELL GmbH (DE) 1997-08-27 EP disclosed