Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | RAB9A | P51151 | 7/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.32 |
| ▸ | DUSP1 | P28562 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2865942 | 0.85 | BRAF (0.49) | BRAFALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL8450229 | 0.82 | RAB9A (0.43) | PRMT5WDR77ALDH1A1RAB9AMEN1 | |
| SCHEMBL14096213 | 0.74 | ALDH1A1 (0.41) | P2RX2ALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL8449792 | 0.73 | ALDH1A1 (0.41) | ALDH1A1RAB9AKDM4ETDP1MAPT | |
| SCHEMBL4373622 | 0.73 | ALDH1A1 (0.47) | P2RX2ALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL2862874 | 0.72 | ALDH1A1 (0.57) | ALDH1A1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL4361359 | 0.72 | KDR (0.46) | ALDH1A1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL4375305 | 0.72 | NPC1 (0.59) | ALDH1A1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL4369912 | 0.71 | KDR (0.45) | ALDH1A1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL2910887 | 0.70 | ALDH1A1 (0.56) | ALDH1A1RAB9AMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365068-B2 | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. (US) | 2008-04-29 | — | — | US | disclosed |
| US-20060025416-A1 | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication | ACHILLION PHARMACEUTICALS, INC. | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025416-A1 | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication | PIGS, NAT1, AADAC | BRAF 4371/4885PRMT5 2836/4885WDR77 3031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.