Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.45 |
| ▸ | HTR2C | P28335 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8451898 | 0.78 | HTR2A (0.42) | HTR2AHTR2CSIGMAR1HTR1A | |
| SCHEMBL8451901 | 0.78 | HTR2A (0.42) | HTR2AHTR2CSIGMAR1HTR1A | |
| SCHEMBL21027978 | 0.77 | HTR2A (0.45) | HTR2AHTR2CKDM4EALDH1A1EGLN2 | |
| SCHEMBL8655509 | 0.74 | HTR2A (0.43) | HTR2AHTR2CSIGMAR1HTR1ANOTUM | |
| SCHEMBL1991214 | 0.73 | HTR2A (0.48) | HTR2AHTR2CSIGMAR1HTR1A | |
| SCHEMBL8655904 | 0.73 | PRKCE (0.51) | HTR2AHTR2CSIGMAR1HTR1A | |
| SCHEMBL8318760 | 0.73 | HTR2A (0.48) | HTR2AHTR2CSIGMAR1HTR1A | |
| SCHEMBL8324461 | 0.73 | HTR2A (0.48) | HTR2AHTR2CSIGMAR1HTR1A | |
| SCHEMBL8452782 | 0.72 | HTR2A (0.44) | HTR2AHTR2CSIGMAR1NOTUM | |
| SCHEMBL8454162 | 0.72 | HTR2A (0.44) | HTR2AHTR2CSIGMAR1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624586-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-09-01 | — | — | EP | disclosed |
| US-5721245-A | ANTIINFLAMMATORY AGENTS, RESPIRATORY SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1998-02-24 | — | — | US | disclosed |
| US-5721230-A | ANTIINFLAMMATORY AGENT, VIRICIDES; TREATING CARDIOVASCULAR DISORDER, RESPIRATORY SYSTEM DISORDER, THROMBOSIS, DIABETES, ALOPECIA | HOFFMANN-LA ROCHE INC. (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0624586-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1994-11-17 | — | — | EP | disclosed |
| EP-0384349-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1994-04-27 | — | — | EP | disclosed |
| EP-0384349-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1990-08-29 | — | — | EP | disclosed |