Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.43 |
| ▸ | HTR2C | P28335 | 5/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8447299 | 0.74 | HTR2A (0.45) | HTR2AHTR2CSIGMAR1HTR1ANOTUM | |
| SCHEMBL8452782 | 0.72 | HTR2A (0.44) | HTR2AHTR2CSIGMAR1NOTUM | |
| SCHEMBL8454162 | 0.72 | HTR2A (0.44) | HTR2AHTR2CSIGMAR1NOTUM | |
| SCHEMBL30684404 | 0.72 | HTR2A (0.44) | HTR2AHTR2CSIGMAR1NOTUM | |
| SCHEMBL8454686 | 0.71 | SIGMAR1 (0.44) | HTR2AHTR2CSIGMAR1 | |
| SCHEMBL8318760 | 0.71 | HTR2A (0.48) | HTR2AHTR2CSIGMAR1HTR1A | |
| SCHEMBL1991214 | 0.71 | HTR2A (0.48) | HTR2AHTR2CSIGMAR1HTR1A | |
| SCHEMBL8655904 | 0.71 | PRKCE (0.51) | HTR2AHTR2CSIGMAR1HTR1A | |
| SCHEMBL8324461 | 0.71 | HTR2A (0.48) | HTR2AHTR2CSIGMAR1HTR1A | |
| SCHEMBL8451901 | 0.70 | HTR2A (0.42) | HTR2AHTR2CSIGMAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5721245-A | ANTIINFLAMMATORY AGENTS, RESPIRATORY SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0384349-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1994-04-27 | — | — | EP | disclosed |
| EP-0384349-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1990-08-29 | — | — | EP | disclosed |