Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCE | Q02156 | 3/20 | 0.51 |
| ▸ | MYLK | Q15746 | 3/20 | 0.51 |
| ▸ | HTR2A | P28223 | 5/20 | 0.45 |
| ▸ | HTR2C | P28335 | 5/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | PRKACG | P22612 | 1/20 | 0.36 |
| ▸ | PRKACB | P22694 | 1/20 | 0.36 |
| ▸ | PRKCH | P24723 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | DKK1 | O94907 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324461 | 0.85 | HTR2A (0.48) | PRKCEMYLKHTR2AHTR2CSIGMAR1 | |
| SCHEMBL8318760 | 0.85 | HTR2A (0.48) | PRKCEMYLKHTR2AHTR2CSIGMAR1 | |
| SCHEMBL1991214 | 0.85 | HTR2A (0.48) | PRKCEMYLKHTR2AHTR2CSIGMAR1 | |
| SCHEMBL1993818 | 0.81 | HTR2A (0.45) | PRKCEMYLKHTR2AHTR2CSIGMAR1 | |
| SCHEMBL8451898 | 0.81 | HTR2A (0.42) | PRKCEMYLKHTR2AHTR2CSIGMAR1 | |
| SCHEMBL8451901 | 0.81 | HTR2A (0.42) | PRKCEMYLKHTR2AHTR2CSIGMAR1 | |
| SCHEMBL8449854 | 0.80 | SIGMAR1 (0.49) | PRKCEMYLKHTR2AHTR2CSIGMAR1 | |
| SCHEMBL8657682 | 0.77 | HTR2A (0.46) | HTR2AHTR2CSIGMAR1 | |
| SCHEMBL8448934 | 0.76 | HTR2A (0.40) | PRKCEMYLKHTR2AHTR2CSIGMAR1 | |
| SCHEMBL6015848 | 0.76 | SIGMAR1 (0.44) | PRKCEMYLKHTR2AHTR2CSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5721245-A | ANTIINFLAMMATORY AGENTS, RESPIRATORY SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0384349-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1994-04-27 | — | — | EP | disclosed |
| EP-0384349-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1990-08-29 | — | — | EP | disclosed |