Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 14/20 | 0.42 |
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | HTR2C | P28335 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8446842 | 0.89 | HTR2A (0.44) | SIGMAR1HTR2AHTR2C | |
| SCHEMBL8453122 | 0.88 | SIGMAR1 (0.38) | SIGMAR1HTR2AHTR2C | |
| SCHEMBL8450784 | 0.81 | HTR2A (0.39) | SIGMAR1HTR2AHTR2C | |
| SCHEMBL8454162 | 0.79 | HTR2A (0.44) | SIGMAR1HTR2AHTR2C | |
| SCHEMBL30684404 | 0.79 | HTR2A (0.44) | SIGMAR1HTR2AHTR2C | |
| SCHEMBL8452782 | 0.79 | HTR2A (0.44) | SIGMAR1HTR2AHTR2C | |
| SCHEMBL8454686 | 0.78 | SIGMAR1 (0.44) | SIGMAR1HTR2AHTR2C | |
| SCHEMBL8446846 | 0.78 | SIGMAR1 (0.46) | SIGMAR1HTR2AHTR2C | |
| SCHEMBL3150583 | 0.77 | KDM4E (0.47) | — | |
| SCHEMBL8454085 | 0.76 | SIGMAR1 (0.43) | SIGMAR1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624586-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-09-01 | — | — | EP | disclosed |
| US-5721230-A | ANTIINFLAMMATORY AGENT, VIRICIDES; TREATING CARDIOVASCULAR DISORDER, RESPIRATORY SYSTEM DISORDER, THROMBOSIS, DIABETES, ALOPECIA | HOFFMANN-LA ROCHE INC. (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0624586-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1994-11-17 | — | — | EP | disclosed |