Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30684404 | 0.85 | HTR2A (0.44) | SIGMAR1HTR2AHTR2C | |
| SCHEMBL8454162 | 0.85 | HTR2A (0.44) | SIGMAR1HTR2AHTR2C | |
| SCHEMBL8452782 | 0.85 | HTR2A (0.44) | SIGMAR1HTR2AHTR2C | |
| SCHEMBL8454686 | 0.83 | SIGMAR1 (0.44) | SIGMAR1HTR2AHTR2CKDM4E | |
| SCHEMBL8446846 | 0.80 | SIGMAR1 (0.46) | SIGMAR1HTR2AHTR2C | |
| SCHEMBL3150583 | 0.77 | KDM4E (0.47) | MEN1KMT2AHSD17B10KDM4EALDH1A1 | |
| SCHEMBL8448530 | 0.76 | SIGMAR1 (0.42) | SIGMAR1HTR2AHTR2C | |
| SCHEMBL8653533 | 0.75 | ALDH1A1 (0.48) | TSHRCYP2C19HSD17B10KDM4EALDH1A1 | |
| SCHEMBL8447283 | 0.75 | HTR2A (0.49) | SIGMAR1HTR2AHTR2CPOLB | |
| SCHEMBL8449854 | 0.73 | SIGMAR1 (0.49) | SIGMAR1HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624586-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-09-01 | — | — | EP | disclosed |
| EP-0624586-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1994-11-17 | — | — | EP | disclosed |