Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP3 | Q9NSD7 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL844852 | 0.90 | L3MBTL1 (0.63) | RXFP3SMN1; SMN2L3MBTL1ALDH1A1MAPT | |
| SCHEMBL18887500 | 0.88 | RXFP3 (0.51) | RXFP3SMN1; SMN2L3MBTL1ALDH1A1MAPT | |
| SCHEMBL5842543 | 0.88 | SMN1; SMN2 (0.55) | RXFP3SMN1; SMN2L3MBTL1ALDH1A1MAPT | |
| SCHEMBL845545 | 0.86 | L3MBTL1 (0.45) | RXFP3SMN1; SMN2L3MBTL1ALDH1A1MAPT | |
| SCHEMBL845812 | 0.82 | L3MBTL1 (0.41) | RXFP3SMN1; SMN2L3MBTL1ALDH1A1MAPT | |
| SCHEMBL5843753 | 0.81 | RXFP3 (0.56) | RXFP3SMN1; SMN2L3MBTL1ALDH1A1MAPT | |
| SCHEMBL871476 | 0.81 | RXFP3 (0.53) | RXFP3SMN1; SMN2L3MBTL1ALDH1A1MAPT | |
| SCHEMBL5842936 | 0.80 | RXFP3 (0.53) | RXFP3SMN1; SMN2L3MBTL1ALDH1A1MAPT | |
| SCHEMBL5843197 | 0.79 | RXFP3 (0.52) | RXFP3SMN1; SMN2L3MBTL1ALDH1A1MAPT | |
| SCHEMBL2176372 | 0.79 | L3MBTL1 (0.76) | SMN1; SMN2L3MBTL1ALDH1A1POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| EP-1893573-B1 | INHIBITORS OF HCV REPLICATION | BRISTOL MYERS SQUIBB CO (US) | 2010-07-21 | — | — | EP | disclosed |