Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.48 |
| ▸ | EP300 | Q09472 | 5/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845211 | 0.92 | EP300 (0.44) | KDM4ELMNAPABPC1EP300CREBBP | |
| SCHEMBL844920 | 0.90 | EP300 (0.48) | EP300CREBBPALDH1A1NPC1MAPK1 | |
| SCHEMBL845295 | 0.88 | KDM4E (0.61) | KDM4ELMNAPABPC1ALDH1A1GAA | |
| SCHEMBL872886 | 0.79 | KDM4E (0.52) | KDM4ELMNAPABPC1ALDH1A1GAA | |
| SCHEMBL845258 | 0.78 | MAPK1 (0.60) | KDM4ELMNAPABPC1EP300CREBBP | |
| SCHEMBL844929 | 0.78 | EP300 (0.53) | PABPC1EP300CREBBPALDH1A1NPC1 | |
| SCHEMBL844832 | 0.75 | KDM4E (0.73) | KDM4ELMNAPABPC1ALDH1A1KDM1A | |
| SCHEMBL845252 | 0.75 | KDM4E (0.73) | KDM4ELMNAPABPC1ALDH1A1KDM1A | |
| SCHEMBL845251 | 0.75 | PABPC1 (0.50) | KDM4ELMNAPABPC1EP300CREBBP | |
| SCHEMBL10281278 | 0.75 | NPC1 (0.76) | LMNAPABPC1EP300CREBBPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |