Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.58 |
| ▸ | CCR8 | P51685 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MPL | P40238 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 10/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SI | P14410 | 1/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.42 |
| ▸ | MBNL1 | Q9NR56 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10268446 | 0.86 | CCR1 (0.56) | CCR1CCR8TGFBR1CYP2A6METAP2 | |
| SCHEMBL29470231 | 0.85 | NPC1 (0.53) | NPC1MPLIDO1GAA | |
| SCHEMBL12856726 | 0.85 | NPC1 (0.53) | NPC1MPLIDO1GAA | |
| SCHEMBL10540892 | 0.81 | KMT2A (0.42) | CCR1CCR8NPC1MPLTGFBR1 | |
| SCHEMBL14732911 | 0.80 | FFAR1 (0.41) | CCR1CCR8NPC1TGFBR1 | |
| SCHEMBL15888380 | 0.79 | CCR1 (0.52) | CCR1CCR8TGFBR1 | |
| SCHEMBL8090286 | 0.79 | CCR1 (0.52) | CCR1CCR8TGFBR1CYP2A6METAP2 | |
| SCHEMBL18807016 | 0.79 | CCR1 (0.62) | CCR1CCR8TGFBR1CYP2A6METAP2 | |
| SCHEMBL10374376 | 0.79 | CCR1 (0.62) | CCR1CCR8NPC1TGFBR1IDO1 | |
| SCHEMBL18952681 | 0.79 | MBNL1 (0.40) | CCR1CCR8NPC1TGFBR1MBNL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040704-B2 | Fluorescent dyes with large stokes shifts | UTI LIMITED PARTNERSHIP (CA) | 2015-05-26 | — | — | US | disclosed |
| US-20140206870-A1 | FLUORSCENT DYES WITH LARGE STOKES SHIFTS | UTI LIMITED PARTNERSHIP (CA) | 2014-07-24 | — | — | US | disclosed |
| EP-2162443-B1 | HETEROARYLAMIDE-SUBSTITUTED PYRIMIDONE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SANOFI SA (FR) | 2013-07-31 | — | — | EP | disclosed |
| WO-2013023292-A1 | FLUORESCENT DYES WITH LARGE STOKES SHIFTS | UTI LIMITED PARTNERSHIP (CA) | 2013-02-21 | — | — | WO | disclosed |
| US-8198287-B2 | Substituted heteroaryl pyridopyrimidone derivatives | SANOFI-AVENTIS (FR) | 2012-06-12 | — | — | US | disclosed |
| US-8198287-B2 | Substituted heteroaryl pyridopyrimidone derivatives | SANOFI-AVENTIS (FR) | 2012-06-12 | — | — | US | disclosed |
| US-20100081677-A1 | HETEROARYLAMIDE PYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2010-04-01 | — | — | US | disclosed |
| US-20100081677-A1 | HETEROARYLAMIDE PYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2010-04-01 | — | — | US | disclosed |
| US-20090306088-A1 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2009-12-10 | — | — | US | disclosed |
| US-20090306088-A1 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2009-12-10 | — | — | US | disclosed |
| WO-2008155666-A2 | HETEROARYLAMIDE-SUBSTITUTED PYRIMIDONE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | SANOFI-AVENTIS (FR) | 2008-12-24 | — | — | WO | disclosed |
| EP-1992621-A1 | Heteroarylamide-substituted pyrimidone derivatives for the treatment of neurodegenerative diseases | Sanofi-Aventis (FR) | 2008-11-19 | — | — | EP | disclosed |
| WO-2008078196-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | disclosed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | disclosed |
| EP-0244130-B1 | PROCESS FOR MAKING 6-ARYL-2-METHYL PYRIDINES | ROHM AND HAAS COMPANY (US) | 1990-01-17 | — | — | EP | disclosed |
| US-4804761-A | Process for making 6-aryl-2-methylpyridines | ROHM AND HAAS COMPANY (US) | 1989-02-14 | — | — | US | disclosed |
| EP-0244130-A2 | Process for making 6-aryl-2-methyl pyridines | ROHM AND HAAS COMPANY (US) | 1987-11-04 | — | — | EP | disclosed |
| EP-0243101-A2 | Insecticidal 6-aryl-pyridine thiosemicarbazones | ROHM AND HAAS COMPANY (US) | 1987-10-28 | — | — | EP | disclosed |
| US-4696938-A | Insecticidal 6-aryl-pyridine thiosemicarbazones | ROHM AND HAAS COMPANY (US) | 1987-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306088-A1 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | GSK3B, GSK3A, GSKIP | CCR1 4539/4885CCR8 4734/4885NPC1 1389/4885 |
| US-20100081677-A1 | HETEROARYLAMIDE PYRIMIDONE DERIVATIVES | DHFR, DPYD, HPRT1 | CCR1 858/4885CCR8 916/4885NPC1 771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.