Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | RHOC | P08134 | 1/20 | 0.43 |
| ▸ | RHOA | P61586 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10119315 | 0.91 | MAPT (0.40) | CYP2C9CYP2C19MAPTALDH1A1MAPK1 | |
| SCHEMBL13272378 | 0.90 | MAPT (0.39) | CYP2C9CYP2C19MAPTALDH1A1MAPK1 | |
| SCHEMBL845013 | 0.89 | CYP2C9 (0.46) | CYP2C9CYP2C19MAPTALDH1A1MAPK1 | |
| SCHEMBL845008 | 0.86 | ALDH1A1 (0.54) | CYP2C9CYP2C19MAPTALDH1A1MAPK1 | |
| SCHEMBL845257 | 0.85 | TRPV1 (0.48) | CYP2C9CYP2C19MAPTALDH1A1MAPK1 | |
| SCHEMBL844996 | 0.85 | CYP2C9 (0.50) | CYP2C9CYP2C19ALDH1A1MAPK1TRPV1 | |
| SCHEMBL845443 | 0.85 | CYP2C9 (0.47) | CYP2C9CYP2C19MAPTALDH1A1MAPK1 | |
| SCHEMBL845007 | 0.83 | PABPC1 (0.49) | CYP2C9CYP2C19ALDH1A1MAPK1TRPV1 | |
| SCHEMBL845131 | 0.83 | PABPC1 (0.49) | CYP2C9CYP2C19ALDH1A1MAPK1TRPV1 | |
| SCHEMBL845458 | 0.83 | CYP2C9 (0.46) | CYP2C9CYP2C19MAPTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |