Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RHOC | P08134 | 1/20 | 0.47 |
| ▸ | RHOA | P61586 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874056 | 0.91 | TRPV1 (0.42) | TRPV1ALDH1A1TSHRCYP2C9CYP2C19 | |
| SCHEMBL845008 | 0.88 | ALDH1A1 (0.54) | ALDH1A1TSHRCYP2C9CYP2C19MEN1 | |
| SCHEMBL845343 | 0.87 | KMT2A (0.50) | TRPV1ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL844996 | 0.87 | CYP2C9 (0.50) | TRPV1ALDH1A1CYP2C9CYP2C19MEN1 | |
| SCHEMBL845443 | 0.87 | CYP2C9 (0.47) | TRPV1ALDH1A1CYP2C9CYP2C19RHOC | |
| SCHEMBL845013 | 0.85 | CYP2C9 (0.46) | TRPV1ALDH1A1CYP2C9CYP2C19RHOC | |
| SCHEMBL845349 | 0.85 | HCRTR1 (0.53) | TRPV1ALDH1A1TSHRCYP2C9CYP2C19 | |
| SCHEMBL845007 | 0.85 | PABPC1 (0.49) | TRPV1ALDH1A1CYP2C9CYP2C19MEN1 | |
| SCHEMBL845458 | 0.85 | CYP2C9 (0.46) | TRPV1ALDH1A1CYP2C9CYP2C19RHOC | |
| SCHEMBL845131 | 0.85 | PABPC1 (0.49) | TRPV1ALDH1A1CYP2C9CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |