Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | CTSE | P14091 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8450331 | 0.92 | REN (0.57) | RENCYP3A4KCNH2CTSDCTSE | |
| SCHEMBL8450946 | 0.92 | REN (0.58) | RENCYP3A4KCNH2CTSDCTSE | |
| SCHEMBL4598172 | 0.81 | REN (0.39) | RENCYP3A4 | |
| SCHEMBL4611135 | 0.76 | REN (0.36) | REN | |
| SCHEMBL8450075 | 0.76 | REN (0.54) | RENCYP3A4CTSDCTSE | |
| SCHEMBL8471262 | 0.73 | REN (0.56) | RENCYP3A4CTSDCTSE | |
| SCHEMBL4938126 | 0.73 | REN (1.00) | RENCYP3A4CTSDCTSE | |
| SCHEMBL8471487 | 0.71 | REN (0.59) | RENCYP3A4CTSDCTSE | |
| SCHEMBL4610652 | 0.67 | REN (0.36) | REN | |
| SCHEMBL4934349 | 0.66 | REN (1.00) | RENCYP3A4CTSDCTSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1908471-A1 | Tetrahydropyridines as renin inhibitors | Speedel Experimenta AG (CH) | 2008-04-09 | — | — | EP | disclosed |