Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.36 |
| ▸ | RARG | P13631 | 10/20 | 0.33 |
| ▸ | RARA | P10276 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.30 |
| ▸ | SELE | P16581 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4597868 | 0.88 | RARG (0.36) | RENRARGRARARARBNR4A2 | |
| SCHEMBL4611135 | 0.87 | REN (0.36) | RENRARGRARARARBNR4A2 | |
| SCHEMBL8450331 | 0.76 | REN (0.57) | REN | |
| SCHEMBL15578151 | 0.71 | KMT2A (0.43) | ALDH1A1 | |
| SCHEMBL6553687 | 0.66 | ALDH1A1 (0.54) | RARBNR4A2ALDH1A1 | |
| SCHEMBL15579121 | 0.66 | HRH3 (0.37) | RARGRARARARBNR4A2ICAM1 | |
| SCHEMBL4598109 | 0.66 | TACR1 (0.35) | — | |
| SCHEMBL4598072 | 0.64 | SLC6A2 (0.38) | REN | |
| SCHEMBL4598067 | 0.64 | SLC6A2 (0.38) | REN | |
| SCHEMBL7317105 | 0.63 | MAPT (0.53) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1908471-A1 | Tetrahydropyridines as renin inhibitors | Speedel Experimenta AG (CH) | 2008-04-09 | — | — | EP | disclosed |