Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP14 | P54578 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | REN | P00797 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 2/20 | 0.41 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4685271 | 0.82 | EGFR (0.49) | ATML3MBTL1ALDH1A1 | |
| SCHEMBL13358189 | 0.79 | USP14 (0.46) | USP14RECQLRENKDM4EMAPK8 | |
| SCHEMBL8451877 | 0.77 | ABCB1 (0.60) | USP14RECQLKDM4EMAPK8ATM | |
| SCHEMBL1998148 | 0.75 | HTR6 (0.46) | KDM4EATMALDH1A1HPGDCYP1A2 | |
| SCHEMBL2676368 | 0.72 | MAPK1 (0.51) | RECQLKDM4EMAPK8L3MBTL1ALDH1A1 | |
| SCHEMBL25919164 | 0.72 | USP14 (0.55) | USP14RECQLKDM4EALDH1A1HPGD | |
| SCHEMBL1993318 | 0.71 | CNR2 (0.55) | CNR1CNR2 | |
| SCHEMBL2883770 | 0.71 | RECQL (0.62) | RECQLKDM4EALDH1A1POLBMEN1 | |
| SCHEMBL2033920 | 0.71 | MEN1 (0.50) | POLBMEN1KMT2ACNR2 | |
| SCHEMBL8702816 | 0.70 | KMT2A (0.62) | KDM4EL3MBTL1ALDH1A1HPGDGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624586-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-09-01 | — | — | EP | disclosed |
| US-5721230-A | ANTIINFLAMMATORY AGENT, VIRICIDES; TREATING CARDIOVASCULAR DISORDER, RESPIRATORY SYSTEM DISORDER, THROMBOSIS, DIABETES, ALOPECIA | HOFFMANN-LA ROCHE INC. (US) | 1998-02-24 | — | — | US | disclosed |
| EP-0624586-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1994-11-17 | — | — | EP | disclosed |