Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.47 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11481976 | 0.82 | VCAM1 (0.62) | VCAM1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8460102 | 0.77 | KDR (0.41) | SLC22A12CYP2C9CYP19A1CYP1A2KDR | |
| SCHEMBL8457999 | 0.75 | CYP19A1 (0.38) | SLC22A12LRRK2MAPTCYP2C9HPGD | |
| SCHEMBL11714812 | 0.75 | VCAM1 (0.54) | VCAM1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL2258930 | 0.73 | VCAM1 (0.58) | VCAM1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL12050816 | 0.73 | HSPB1 (0.55) | MAPTPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL24750303 | 0.71 | VCAM1 (0.49) | VCAM1MAPTCYP2C9HPGDTDP1 | |
| SCHEMBL29938779 | 0.71 | VCAM1 (0.49) | VCAM1MAPTCYP2C9HPGDTDP1 | |
| SCHEMBL7689338 | 0.70 | VCAM1 (0.54) | VCAM1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL23887905 | 0.68 | MAOB (0.65) | VCAM1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922045-A1 | BICYCLIC PYRIMIDINE DERIVATIVES AND THEIR USE AS ANTI-COAGULANTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-06-16 | — | — | EP | disclosed |
| WO-1998007723-A1 | BICYCLIC PYRIMIDINE DERIVATIVES AND THEIR USE AS ANTI-COAGULANTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-02-26 | — | — | WO | disclosed |