Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | PYGL | P06737 | 1/20 | 0.37 |
| ▸ | PYGM | P11217 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20522700 | 0.80 | KDR (0.46) | KDRMAPK14BRAFTNNI3KMRGPRX4 | |
| SCHEMBL12484107 | 0.80 | KMO (0.52) | KDRMAPK14BRAFTNNI3KMRGPRX4 | |
| SCHEMBL7454153 | 0.79 | PPARG (0.48) | MRGPRX4CYP19A1PYGLPYGMCYP1A2 | |
| SCHEMBL8451586 | 0.77 | VCAM1 (0.47) | KDRMAPK14BRAFTNNI3KSLC22A12 | |
| SCHEMBL8457999 | 0.75 | CYP19A1 (0.38) | KDRMAPK14BRAFTNNI3KSLC22A12 | |
| SCHEMBL4548784 | 0.73 | KDR (0.67) | KDRMAPK14BRAFTNNI3K | |
| SCHEMBL4309752 | 0.71 | SMN1; SMN2 (0.54) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL11891840 | 0.70 | SRD5A2 (0.54) | KDRMAPK14BRAFTNNI3K | |
| SCHEMBL4303621 | 0.68 | KDR (0.42) | KDRMAPK14BRAFTNNI3KKMO | |
| SCHEMBL18906059 | 0.67 | SRD5A2 (0.48) | KDRMAPK14BRAFTNNI3KCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922045-A1 | BICYCLIC PYRIMIDINE DERIVATIVES AND THEIR USE AS ANTI-COAGULANTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-06-16 | — | — | EP | disclosed |
| WO-1998007723-A1 | BICYCLIC PYRIMIDINE DERIVATIVES AND THEIR USE AS ANTI-COAGULANTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-02-26 | — | — | WO | disclosed |