Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | UCHL1 | P09936 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 9/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845227 | 0.76 | NPC1 (0.76) | NPC1LMNANPSR1POLBUSP30 | |
| SCHEMBL10281278 | 0.76 | NPC1 (0.76) | NPC1LMNANPSR1POLBUSP30 | |
| SCHEMBL10299164 | 0.76 | NPC1 (0.76) | NPC1LMNANPSR1POLBUSP30 | |
| SCHEMBL26364450 | 0.74 | USP30 (0.51) | NPC1UCHL1LMNANPSR1HSD17B10 | |
| SCHEMBL26364434 | 0.74 | USP30 (0.51) | NPC1UCHL1LMNANPSR1HSD17B10 | |
| SCHEMBL3835668 | 0.74 | USP30 (0.55) | NPC1UCHL1LMNANPSR1HSD17B10 | |
| SCHEMBL26364407 | 0.74 | USP30 (0.51) | NPC1UCHL1LMNANPSR1HSD17B10 | |
| SCHEMBL13375890 | 0.73 | ALDH1A1 (0.53) | NPC1UCHL1LMNANPSR1POLB | |
| SCHEMBL3847566 | 0.73 | ALDH1A1 (0.53) | NPC1UCHL1LMNANPSR1POLB | |
| SCHEMBL3830118 | 0.73 | UCHL1 (0.49) | NPC1UCHL1LMNANPSR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |