Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845360 | 0.98 | ALDH1A1 (0.40) | ALDH1A1CES2CES1ADRB2ADRB1 | |
| SCHEMBL10099631 | 0.83 | ALDH1A1 (0.50) | ALDH1A1CES2CES1ADRB2ADRB1 | |
| SCHEMBL5515831 | 0.81 | GABRP (0.41) | ALDH1A1MEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL16573650 | 0.79 | ALDH1A1 (0.47) | ALDH1A1CES2CES1ADRB2ADRB1 | |
| SCHEMBL1816297 | 0.79 | MAPT (0.41) | ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL23780852 | 0.78 | ADRB2 (0.52) | ALDH1A1CES2CES1ADRB2ADRB1 | |
| SCHEMBL7697151 | 0.76 | ALDH1A1 (0.49) | ALDH1A1CES2CES1ADRB2ADRB1 | |
| SCHEMBL11374216 | 0.76 | ALDH1A1 (0.49) | ALDH1A1CES2CES1ADRB2ADRB1 | |
| SCHEMBL27831635 | 0.76 | ALDH1A1 (0.45) | ALDH1A1CES2CES1ADRB2ADRB1 | |
| SCHEMBL24621845 | 0.75 | ALDH1A1 (0.47) | ALDH1A1CES2CES1ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 187 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016204991-A1 | IBRUTINIB PRODRUGS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USE | NGUYEN MARK QUANG (US) | 2016-12-22 | — | — | WO | claimed |
| US-9394312-B1 | Ibrutinib prodrugs, pharmaceutical compositions thereof, and methods of use | Nguyen, Mark Quang (US) | 2016-07-19 | — | — | US | claimed |
| WO-2007054965-A2 | PROCESS FOR PREPARATION OF TETRAZOLES FROM AROMATIC CYANO DERIVATIVES | ALEMBIC LIMITED (IN) | 2007-05-18 | — | — | WO | claimed |
| EP-0720982-B1 | Benzimidazole derivatives, their production and use and use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-11-13 | — | — | EP | claimed |
| EP-0603712-B1 | Heterocyclic compounds having angiotensin II antagonistic activity and use thereof | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-08-16 | — | — | EP | claimed |
| US-6242600-B1 | ANTIISCHEMIC AGENTS, ANTICOAGULANTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-06-05 | — | — | US | claimed |
| EP-0668272-B1 | A process for the production of tetrazolyl compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-07-12 | — | — | EP | claimed |
| EP-0970071-A1 | 2-PEPERAZINONE-1-ACETIC ACID DERIVATIVES AND THEIR USE | Takeda Chemical Industries, Ltd. (JP) | 2000-01-12 | — | — | EP | claimed |
| WO-1998039324-A1 | 2-PEPERAZINONE-1-ACETIC ACID DERIVATIVES AND THEIR USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-09-11 | — | — | WO | claimed |
| EP-0720982-A1 | Benzimidazole derivatives, their production and use and use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-07-10 | — | — | EP | claimed |
| US-5496835-A | HYPOTENSIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | claimed |
| EP-0603712-A2 | Heterocyclic compounds having angiotensin II antagonistic activity and use thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-06-29 | — | — | EP | claimed |
| EP-1579872-B1 | BODY WEIGHT GAIN INHIBITOR | TAKEDA PHARMACEUTICAL (JP) | 2012-03-28 | — | — | EP | disclosed |
| EP-2277520-A2 | A pharmaceutical composition for angiotensin ii-mediated diseases | Takeda Pharmaceutical Company Limited (JP) | 2011-01-26 | — | — | EP | disclosed |
| EP-2253327-A1 | Pharmaceutical composition containing a compound having angiotensin II antagonistic activity in combination with another compound | Takeda Pharmaceutical Company Limited (JP) | 2010-11-24 | — | — | EP | disclosed |
| EP-1153613-B1 | PERCUTANEOUS ABSORPTION PREPARATIONS OF COMPOUND HAVING ANGIOTENSIN II RECEPTOR ANTAGONISM | TAKEDA PHARMACEUTICAL (JP) | 2010-11-10 | — | — | EP | disclosed |
| EP-0483683-A2 | Thienoimidazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1992-05-06 | — | — | EP | disclosed |
| EP-0459136-A1 | Benzimidazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-12-04 | — | — | EP | disclosed |
| US-4933355-A | ALDOSE REDUCTASE INHIBITORS | SANKYO COMPANY LIMITED (JP) | 1990-06-12 | — | — | US | disclosed |
| EP-0337819-A1 | Thiazole derivatives, their preparation and their use in the treatment of diabetes complications | Sankyo Company Limited (JP) | 1989-10-18 | — | — | EP | disclosed |