Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 5/20 | 0.52 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL844903 | 0.82 | EP300 (0.51) | EP300CREBBPTSHRALDH1A1MAPK1 | |
| SCHEMBL2193086 | 0.82 | EP300 (0.46) | EP300CREBBPTSHRALDH1A1MAPK1 | |
| SCHEMBL873777 | 0.80 | EP300 (0.49) | EP300CREBBPTSHRALDH1A1CYP2C19 | |
| SCHEMBL844890 | 0.80 | KCNH2 (0.51) | TSHRALDH1A1MAPK1HTTCYP2C9 | |
| SCHEMBL845488 | 0.77 | CYP2C19 (0.48) | TSHRALDH1A1MAPK1HTTCYP2C9 | |
| SCHEMBL845202 | 0.77 | CYP2C19 (0.48) | TSHRALDH1A1MAPK1HTTCYP2C9 | |
| SCHEMBL845759 | 0.77 | CYP2C19 (0.48) | TSHRALDH1A1MAPK1HTTCYP2C9 | |
| SCHEMBL10120083 | 0.75 | CPT2 (0.46) | EP300CREBBPTSHRALDH1A1PABPC1 | |
| SCHEMBL28826383 | 0.75 | OGG1 (0.46) | TSHRALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL844894 | 0.75 | CYP2C19 (0.55) | TSHRALDH1A1MAPK1HTTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |