Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 19/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 19/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 18/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3753704 | 0.72 | LMNA (0.38) | — | |
| SCHEMBL10153521 | 0.71 | HTR6 (0.46) | HTR6 | |
| SCHEMBL13058318 | 0.70 | LMNA (0.36) | — | |
| SCHEMBL15934892 | 0.69 | CASP7 (0.31) | — | |
| SCHEMBL22260060 | 0.68 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3HTR6CYP2D6 | |
| SCHEMBL16144637 | 0.68 | SLC6A2 (0.32) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL6489756 | 0.68 | SLC6A2 (0.32) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL5839027 | 0.67 | CHRM2 (0.37) | SLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL6011701 | 0.65 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL27269213 | 0.65 | SLC6A4 (0.42) | SLC6A2SLC6A4SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432555-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135650-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2010-11-25 | — | — | WO | disclosed |