Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 7/20 | 0.58 |
| ▸ | RARG | P13631 | 7/20 | 0.58 |
| ▸ | RARA | P10276 | 6/20 | 0.58 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | PGR | P06401 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.58 |
| ▸ | BLVRB | P30043 | 1/20 | 0.58 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8459822 | 0.81 | RARB (0.65) | RARBRARGRARACYP26A1MEN1 | |
| SCHEMBL9868167 | 0.81 | RARB (0.65) | RARBRARGRARACYP26A1MEN1 | |
| SCHEMBL7691901 | 0.80 | RARB (0.64) | RARBRARGRARACYP26A1MEN1 | |
| SCHEMBL8458419 | 0.80 | RARB (0.64) | RARBRARGRARACYP26A1MEN1 | |
| SCHEMBL8458901 | 0.80 | RARB (0.64) | RARBRARGRARACYP26A1MEN1 | |
| Tamibarotene SCHEMBL36207 | 0.74 | RARB (1.00) | RARBRARGRARACYP26A1MEN1 | |
| Tamibarotene SCHEMBL29373818 | 0.74 | RARB (1.00) | RARBRARGRARACYP26A1MEN1 | |
| SCHEMBL8460471 | 0.73 | RXRA (0.52) | RARBRARGRARACYP26A1MEN1 | |
| Tamibarotene SCHEMBL21055743 | 0.73 | RARB (0.97) | RARBRARGRARACYP26A1MEN1 | |
| SCHEMBL8522300 | 0.73 | RARB (0.58) | RARBRARGRARACYP26A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024344-A1 | USE OF RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5489611-A | ADMINISTERING A RETINOID COMPOUND | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |