Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 13/20 | 0.64 |
| ▸ | RARG | P13631 | 13/20 | 0.64 |
| ▸ | RARA | P10276 | 9/20 | 0.64 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | PGR | P06401 | 1/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.64 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.64 |
| ▸ | BLVRB | P30043 | 1/20 | 0.64 |
| ▸ | RXRA | P19793 | 13/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | RXRB | P28702 | 9/20 | 0.52 |
| ▸ | RXRG | P48443 | 7/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8459822 | 0.85 | RARB (0.65) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL9868167 | 0.85 | RARB (0.65) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8458419 | 0.84 | RARB (0.64) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8458901 | 0.84 | RARB (0.64) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7698741 | 0.83 | RARA (0.48) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8469432 | 0.82 | RARG (0.50) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL8458254 | 0.80 | RARB (0.58) | RARBRARGRARACYP26A1CYP3A4 | |
| Tamibarotene SCHEMBL29373818 | 0.78 | RARB (1.00) | RARBRARGRARACYP26A1CYP3A4 | |
| Tamibarotene SCHEMBL36207 | 0.78 | RARB (1.00) | RARBRARGRARACYP26A1CYP3A4 | |
| SCHEMBL7155475 | 0.78 | RARB (0.67) | RARBRARGRARACYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876330-B1 | ARYL OR HETEROARYL AMIDES OF TETRAHYDRONAPHTHALENE, CHROMAN, THIOCHROMAN AND 1,2,3,4-TETRAHYDROQUINOLINE CARBOXYLIC ACIDS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES INC (US) | 2001-03-28 | — | — | EP | claimed |
| US-6342602-B1 | BIND SPECIFICALLY OR SELECTIVELY TO RAR-ALPHA RECEPTORS | ALLERGAN SALES, INC. | 2002-01-29 | — | — | US | disclosed |
| EP-0876330-B1 | ARYL OR HETEROARYL AMIDES OF TETRAHYDRONAPHTHALENE, CHROMAN, THIOCHROMAN AND 1,2,3,4-TETRAHYDROQUINOLINE CARBOXYLIC ACIDS HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN SALES INC (US) | 2001-03-28 | — | — | EP | disclosed |
| US-6124455-A | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity | ALLERGAN SALES, INC. (US) | 2000-09-26 | — | — | US | disclosed |
| US-6034244-A | ANTIINFLAMMATORY AGENTS; SKIN DISORDERS; ANTICANCER AGENT | ALLERGAN SALES, INC. (US) | 2000-03-07 | — | — | US | disclosed |
| US-5675024-A | RETINOID RECEPTOR AGONISTS | ALLERGAN (US) | 1997-10-07 | — | — | US | disclosed |