SCHEMBL8458346

SCHEMBL8458346

Fc1cc(Br)c(Cl)cc1Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 4/20 0.44
ALDH1A1 P00352 2/20 0.38
TDP1 Q9NUW8 1/20 0.38
CSNK2A1 P68400 1/20 0.35
KDM1A O60341 6/20 0.35
KDM1B Q8NB78 4/20 0.35
MAPT P10636 2/20 0.34
GPR84 Q9NQS5 1/20 0.32
CYP3A4 P08684 1/20 0.32
ALPL P05186 1/20 0.31
NPC1 O15118 1/20 0.31
RAB9A P51151 1/20 0.31
MAPK1 P28482 1/20 0.30
KCNH2 Q12809 2/20 0.30
MEN1 O00255 1/20 0.30
HTT P42858 1/20 0.30
KMT2A Q03164 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30214380 1.00 AHR (0.44) AHRALDH1A1TDP1CSNK2A1KDM1A
SCHEMBL17543931 0.89 AHR (0.44) AHRALDH1A1TDP1CSNK2A1KDM1A
SCHEMBL1759465 0.86 AHR (0.46) AHRALDH1A1TDP1CSNK2A1KDM1A
SCHEMBL31070107 0.83 KDM1A (0.44) AHRALDH1A1TDP1KDM1AKDM1B
SCHEMBL1397113 0.83 KDM1A (0.44) AHRALDH1A1TDP1KDM1AKDM1B
SCHEMBL7534006 0.78 ALDH1A1 (0.46) AHRALDH1A1TDP1KDM1AKDM1B
SCHEMBL11282194 0.78 AHR (0.55) AHRALDH1A1CSNK2A1MAPTCYP3A4
SCHEMBL23539570 0.78 KDM1A (0.48) AHRALDH1A1TDP1KDM1AKDM1B
SCHEMBL21218760 0.78 AHR (0.44) AHRCSNK2A1KDM1AKDM1BNPC1
SCHEMBL30892371 0.78 KDM1A (0.48) AHRALDH1A1TDP1KDM1AKDM1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115850018-B Synthesis method of 1,2, 4-trifluoro benzene 阜新睿光氟化学有限公司 2024-10-18 CN claimed
CN-115677477-B Preparation method of 2,4, 5-trifluoro-phenylacetic acid and intermediate thereof 上海康鹏科技股份有限公司 2023-05-26 CN claimed
CN-115850018-A Synthesis method of 1,2, 4-trifluorobenzene 阜新睿光氟化学有限公司 2023-03-28 CN claimed
CN-115677477-A Preparation method of 2,4, 5-trifluoro-phenylacetic acid and intermediate thereof 上海康鹏科技股份有限公司 2023-02-03 CN claimed
EP-0500083-B1 Process for the preparation of 2,4-dichloro-5-fluorobenzonitrile HOECHST AG (DE) 1995-09-13 EP claimed
US-5187295-A PROCESS FOR THE PREPARATION OF 2,4-DICHLORO-5-FLUOROBENZONITRILE HOECHST AKTIENGESELLSCHAFT (DE) 1993-02-16 US claimed
EP-0500083-A2 Process for the preparation of 2,4-dichloro-5-fluorobenzonitrile HOECHST AKTIENGESELLSCHAFT (DE) 1992-08-26 EP claimed
CN-115850018-B Synthesis method of 1,2, 4-trifluoro benzene 阜新睿光氟化学有限公司 2024-10-18 CN disclosed
CN-115850018-B Synthesis method of 1,2, 4-trifluoro benzene 阜新睿光氟化学有限公司 2024-10-18 CN disclosed
CN-115677477-B Preparation method of 2,4, 5-trifluoro-phenylacetic acid and intermediate thereof 上海康鹏科技股份有限公司 2023-05-26 CN disclosed
CN-115677477-B Preparation method of 2,4, 5-trifluoro-phenylacetic acid and intermediate thereof 上海康鹏科技股份有限公司 2023-05-26 CN disclosed
CN-115850018-A Synthesis method of 1,2, 4-trifluorobenzene 阜新睿光氟化学有限公司 2023-03-28 CN disclosed
CN-115850018-A Synthesis method of 1,2, 4-trifluorobenzene 阜新睿光氟化学有限公司 2023-03-28 CN disclosed
EP-0557949-A2 Process for the preparation of 2,4,5 trifluorobenzonitrile HOECHST AKTIENGESELLSCHAFT (DE) 1993-09-01 EP disclosed
US-5241111-A Trichloromethylating a fluorobenzene, reacting with aqueous ammonia, fluorinating, hydrolyzing ASAHI GLASS COMPANY LTD. (JP) 1993-08-31 US disclosed
US-5187295-A PROCESS FOR THE PREPARATION OF 2,4-DICHLORO-5-FLUOROBENZONITRILE HOECHST AKTIENGESELLSCHAFT (DE) 1993-02-16 US disclosed
US-5187295-A PROCESS FOR THE PREPARATION OF 2,4-DICHLORO-5-FLUOROBENZONITRILE HOECHST AKTIENGESELLSCHAFT (DE) 1993-02-16 US disclosed
EP-0500083-A2 Process for the preparation of 2,4-dichloro-5-fluorobenzonitrile HOECHST AKTIENGESELLSCHAFT (DE) 1992-08-26 EP disclosed
EP-0500083-A2 Process for the preparation of 2,4-dichloro-5-fluorobenzonitrile HOECHST AKTIENGESELLSCHAFT (DE) 1992-08-26 EP disclosed
EP-0431373-A2 Processes for producing 5-fluorbenzoic acids and their intermediates ASAHI GLASS COMPANY LTD. (JP) 1991-06-12 EP disclosed