Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 4/20 | 0.57 |
| ▸ | RARB | P10826 | 4/20 | 0.57 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | ACR | P10323 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4516578 | 0.92 | CA12 (0.46) | RARARARBKMT2AMAPTALDH1A1 | |
| SCHEMBL9850151 | 0.91 | MAPT (0.48) | RARARARBPRSS1ACRKMT2A | |
| SCHEMBL8759294 | 0.91 | RARA (0.54) | RARARARBPRSS1ACRKMT2A | |
| SCHEMBL9850207 | 0.87 | RARB (0.47) | RARARARBPRSS1ACRKMT2A | |
| SCHEMBL8460713 | 0.87 | RARA (0.58) | RARARARBPRSS1ACRKMT2A | |
| SCHEMBL9850206 | 0.86 | HIF1A (0.49) | RARARARBKMT2AMAPTALDH1A1 | |
| SCHEMBL9850145 | 0.86 | SSTR5 (0.46) | RARARARBHSD17B10HIF1ARARG | |
| SCHEMBL5736766 | 0.83 | CYP26B1 (0.48) | RARARARBPRSS1HIF1A | |
| SCHEMBL9850216 | 0.83 | RARA (0.49) | RARARARBPRSS1ACRKMT2A | |
| SCHEMBL8760027 | 0.83 | MAPT (0.48) | RARARARBPRSS1ACRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4139178-A | — | — | None | — | — | JP | disclosed |
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024344-A1 | USE OF RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5489611-A | ADMINISTERING A RETINOID COMPOUND | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |
| JP-H04139178-A | CHROMAN ESTER HAVING RETINOID-LIKE ACTIVITY | ALLERGAN INC | 1992-05-13 | — | — | JP | disclosed |
| EP-0435681-A1 | Chroman esters of phenols and benzoic acids having retinoid-like activity | ALLERGAN, INC. (US) | 1991-07-03 | — | — | EP | disclosed |
| US-5006550-A | Skin disorder, arthritis, wound healing agents, dry eye syndrome | ALLERGAN, INC. (US) | 1991-04-09 | — | — | US | disclosed |