Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | RARA | P10276 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | RARB | P10826 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | RARG | P13631 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TOP1 | P11387 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8458858 | 0.91 | HTT (0.57) | MEN1KMT2AMITFCYP26A1CYP3A4 | |
| SCHEMBL13816279 | 0.89 | LMNA (0.59) | KMT2AALDH1A1GAAHTTLMNA | |
| SCHEMBL9944064 | 0.84 | PKM (0.54) | MEN1KMT2AMITFCYP26A1CYP3A4 | |
| SCHEMBL13816269 | 0.81 | ACE2 (0.61) | MEN1KMT2AALDH1A1CYP1A2TSHR | |
| SCHEMBL7822088 | 0.79 | MEN1 (0.58) | MEN1KMT2AMITFCYP26A1CYP3A4 | |
| SCHEMBL26915306 | 0.79 | LMNA (0.68) | MEN1KMT2AMITFALDH1A1FFAR1 | |
| SCHEMBL8461727 | 0.79 | LMNA (0.68) | MEN1KMT2AMITFALDH1A1FFAR1 | |
| SCHEMBL8556508 | 0.77 | P4HTM (0.51) | MEN1KMT2AALDH1A1LMNANPC1 | |
| SCHEMBL6242641 | 0.77 | MEN1 (0.81) | MEN1KMT2AMITFCYP26A1CYP3A4 | |
| SCHEMBL28419632 | 0.77 | MITF (0.81) | MEN1KMT2AMITFFFAR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024344-A1 | USE OF RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5489611-A | ADMINISTERING A RETINOID COMPOUND | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |