Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 12/20 | 0.63 |
| ▸ | RARB | P10826 | 12/20 | 0.63 |
| ▸ | RARG | P13631 | 12/20 | 0.63 |
| ▸ | CYP26A1 | O43174 | 7/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | PGR | P06401 | 1/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.60 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.60 |
| ▸ | BLVRB | P30043 | 1/20 | 0.60 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8458887 | 1.00 | RARA (0.63) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL727915 | 0.86 | RARA (0.66) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL8461840 | 0.86 | CYP26A1 (0.80) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL9446527 | 0.86 | CYP26A1 (0.80) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL12646806 | 0.85 | RARG (0.65) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL1615305 | 0.83 | RARB (0.74) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL1615307 | 0.83 | RARB (0.74) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL1615386 | 0.83 | RARB (0.74) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL10645941 | 0.83 | RARB (0.68) | RARARARBRARGCYP26A1CYP3A4 | |
| SCHEMBL10645938 | 0.83 | RARB (0.68) | RARARARBRARGCYP26A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999048529-A1 | RETINOID-GLITAZONE COMBINATIONS | WARNER-LAMBERT COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |
| EP-0808159-A1 | USE OR RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024344-A1 | USE OF RETINOIDS TO LOWER PLASMA LEVELS OF LIPOPROTEIN (a) | WARNER-LAMBERT COMPANY (US) | 1996-08-15 | — | — | WO | disclosed |
| US-5489611-A | ADMINISTERING A RETINOID COMPOUND | WARNER-LAMBERT COMPANY (US) | 1996-02-06 | — | — | US | disclosed |