Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.41 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | F2R | P25116 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29101876 | 1.00 | GABRA1 (0.41) | GABRA1GABRB2CLCN2CYP2D6CYP2C19 | |
| SCHEMBL29101886 | 0.84 | ALDH1A1 (0.38) | CYP2D6CYP2C19KDM4EMEN1KMT2A | |
| SCHEMBL15999947 | 0.83 | GABRA1 (0.41) | GABRA1GABRB2CLCN2MEN1KMT2A | |
| SCHEMBL19139647 | 0.83 | GABRA1 (0.41) | GABRA1GABRB2CLCN2MEN1KMT2A | |
| SCHEMBL17133918 | 0.82 | GABRA1 (0.42) | GABRA1GABRB2CLCN2CYP2D6CYP2C19 | |
| SCHEMBL15761233 | 0.82 | GABRA1 (0.42) | GABRA1GABRB2CLCN2CYP2D6CYP2C19 | |
| SCHEMBL15946909 | 0.82 | GABRA1 (0.40) | GABRA1GABRB2CLCN2CYP2D6MEN1 | |
| SCHEMBL17192802 | 0.82 | CYP2D6 (0.38) | CYP2D6CYP2C19KDM4EMEN1KMT2A | |
| SCHEMBL15946906 | 0.82 | GABRA1 (0.40) | GABRA1GABRB2CLCN2CYP2D6MEN1 | |
| SCHEMBL20342728 | 0.80 | GABRA1 (0.39) | GABRA1GABRB2CLCN2CTBP2F2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090076088-A1 | Thrombin Receptor Antagonists | SCHERING CORPORATION | 2009-03-19 | — | — | US | disclosed |
| US-20090069383-A1 | Thrombin Receptor Antagonists | SCHERING CORPORATION | 2009-03-12 | — | — | US | disclosed |
| US-7488742-B2 | Thrombin receptor antagonists | SCHERING CORPORATION (US) | 2009-02-10 | — | — | US | disclosed |
| US-20040152736-A1 | Thrombin receptor antagonists | TOPROL ACQUISITION LLC | 2004-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076088-A1 | Thrombin Receptor Antagonists | CNR1, CNR2, TBXA2R | GABRA1 136/4885GABRB2 263/4885CLCN2 3053/4885 |
| US-20040152736-A1 | Thrombin receptor antagonists | CNR1, TBXA2R, CNR2 | GABRA1 108/4885GABRB2 232/4885CLCN2 2424/4885 |
| US-20090069383-A1 | Thrombin Receptor Antagonists | CNR1, CNR2, TBXA2R | GABRA1 136/4885GABRB2 263/4885CLCN2 3053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.