Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperidine SCHEMBL10726327 | 0.97 | ALDH1A1 (0.53) | ALDH1A1CXCR4SMN1; SMN2NOS2KDM4E | |
| Pyrrolidine SCHEMBL6853053 | 0.97 | ALDH1A1 (0.50) | ALDH1A1CXCR4SMN1; SMN2NOS2KDM4E | |
| Pyrrolidine SCHEMBL2219944 | 0.97 | — | — | |
| Piperidine SCHEMBL11035777 | 0.94 | ALDH1A1 (0.56) | ALDH1A1CXCR4SMN1; SMN2NOS2KDM4E | |
| Pyrrolidine SCHEMBL5823457 | 0.94 | ALDH1A1 (0.47) | ALDH1A1CXCR4SMN1; SMN2NOS2KDM4E | |
| Piperidine SCHEMBL7564193 | 0.94 | ALDH1A1 (0.56) | ALDH1A1CXCR4SMN1; SMN2NOS2KDM4E | |
| Piperidine SCHEMBL9749275 | 0.91 | ALDH1A1 (0.53) | ALDH1A1CXCR4SMN1; SMN2NOS2KDM4E | |
| Aziridine SCHEMBL29603143 | 0.87 | — | — | |
| Piperidine SCHEMBL9644995 | 0.84 | ALDH1A1 (0.60) | ALDH1A1CXCR4SMN1; SMN2NOS2KDM4E | |
| Piperazine SCHEMBL28283221 | 0.83 | HIF1A (0.46) | CXCR4SMN1; SMN2NOS2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666741-B1 | DITHIOCARBAMATES FOR THE TREATMENT OF ATHEROSCLEROSIS AND OTHER CARDIOVASCULAR AND INFLAMMATORY DISEASES | UNIV EMORY (US) | 1999-08-11 | — | — | EP | disclosed |
| US-5877203-A | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases | EMORY UNIVERSITY (US) | 1999-03-02 | — | — | US | disclosed |
| US-5792787-A | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases | EMORY UNIVERSITY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0666741-A1 | DITHIOCARBAMATES FOR THE TREATMENT OF ATHEROSCLEROSIS AND OTHER CARDIOVASCULAR AND INFLAMMATORY DISEASES | EMORY UNIVERSITY (US) | 1995-08-16 | — | — | EP | disclosed |
| US-5380747-A | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases | EMORY UNIVERSITY (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1994009772-A1 | DITHIOCARBAMATES FOR THE TREATMENT OF ATHEROSCLEROSIS AND OTHER CARDIOVASCULAR AND INFLAMMATORY DISEASES | EMORY UNIVERSITY (US) | 1994-05-11 | — | — | WO | disclosed |