Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 5/20 | 0.38 |
| ▸ | DRD3 | P35462 | 4/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8462998 | 0.92 | HSD11B1 (0.41) | OPRM1HTR2ADRD4DRD3ACHE | |
| SCHEMBL8468465 | 0.88 | HTR4 (0.41) | HTR2ADRD3ACHESIGMAR1CYP1A2 | |
| SCHEMBL8462968 | 0.86 | HTR4 (0.45) | HTR2ADRD3ACHESIGMAR1CYP1A2 | |
| SCHEMBL8462836 | 0.85 | HTR4 (0.44) | HTR2ADRD3ACHESIGMAR1CYP1A2 | |
| SCHEMBL8463846 | 0.85 | HTR4 (0.44) | HTR2ADRD3ACHESIGMAR1CYP1A2 | |
| SCHEMBL8462522 | 0.85 | HTR4 (0.44) | HTR2ADRD3ACHESIGMAR1CYP1A2 | |
| SCHEMBL8468663 | 0.85 | HTR4 (0.44) | HTR2ADRD3ACHESIGMAR1CYP1A2 | |
| SCHEMBL8463702 | 0.85 | HTR4 (0.44) | HTR2ADRD3ACHESIGMAR1CYP1A2 | |
| SCHEMBL8466504 | 0.85 | HTR4 (0.44) | HTR2ADRD3ACHESIGMAR1CYP1A2 | |
| SCHEMBL8321487 | 0.66 | HTR1A (0.47) | HTR2AMEN1KMT2AALDH1A1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0604494-B1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-28 | — | — | EP | claimed |