Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 4/20 | 0.53 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.53 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | GABRP | O00591 | 2/20 | 0.46 |
| ▸ | GABRD | O14764 | 2/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.46 |
| ▸ | GABRE | P78334 | 2/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL14157640 | 1.00 | TP53 (0.65) | TP53TSHREGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL14157638 | 1.00 | TP53 (0.65) | TP53TSHREGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL8460431 | 1.00 | TP53 (0.65) | TP53TSHREGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL746756 | 0.97 | TP53 (0.69) | TP53TSHREGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL989414 | 0.97 | TP53 (0.69) | TP53TSHREGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL746753 | 0.97 | TP53 (0.69) | TP53TSHREGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL16681176 | 0.94 | TP53 (0.65) | TP53TSHREGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL16681178 | 0.94 | TP53 (0.65) | TP53TSHREGLN1EGLN3HCAR2 | |
| Fumaric Acid SCHEMBL7489586 | 0.84 | TSHR (0.64) | TP53TSHREGLN1EGLN3HCAR2 | |
| Maleic Acid SCHEMBL27659186 | 0.84 | TSHR (0.64) | TP53TSHREGLN1EGLN3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999065337-A1 | DIETARY SUPPLEMENT FOR POST-MENOPAUSAL WOMEN | BETH ISRAEL DEACONESS MEDICAL CENTER (US) | 1999-12-23 | — | — | WO | claimed |