Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.33 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845787 | 0.74 | TNKS (0.43) | RAB9ANPC1SERPINE1HTTATM | |
| SCHEMBL846515 | 0.71 | TRPV1 (0.48) | RAB9ANPC1TRPV1SMN1; SMN2HDAC3 | |
| SCHEMBL846832 | 0.71 | TRPV1 (0.60) | RAB9ANPC1SERPINE1HTTATM | |
| SCHEMBL846514 | 0.71 | TRPV1 (0.68) | RAB9ANPC1HTTATMTRPV1 | |
| SCHEMBL846284 | 0.70 | RAB9A (0.57) | RAB9ANPC1SERPINE1HTTSMN1; SMN2 | |
| SCHEMBL6383953 | 0.66 | HTT (0.49) | RAB9ANPC1HTTATMSMN1; SMN2 | |
| SCHEMBL846141 | 0.65 | MAPT (0.42) | NPC1HTTATMTRPV1ALDH1A1 | |
| SCHEMBL846079 | 0.64 | NPC1 (0.43) | RAB9ANPC1TRPV1 | |
| SCHEMBL846031 | 0.61 | IRAK4 (0.43) | RAB9ANPC1HTTTRPV1MAOB | |
| SCHEMBL860046 | 0.60 | TRPV1 (0.67) | RAB9ANPC1TRPV1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | claimed |