SCHEMBL8460641

SCHEMBL8460641

C#CC(C)(C)O[SiH](Cc1ccccc1)OC(C)(C)C#C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 1/20 0.34
TAAR1 Q96RJ0 1/20 0.34
MAOB P27338 6/20 0.33
TSHR P16473 4/20 0.33
MAOA P21397 4/20 0.33
LMNA P02545 3/20 0.33
CYP3A4 P08684 2/20 0.33
USP2 O75604 1/20 0.33
PYCR1 P32322 1/20 0.33
ALDH1A1 P00352 1/20 0.33
BLM P54132 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
CYP2D6 P10635 3/20 0.32
PDE2A O00408 1/20 0.32
CYP1A2 P05177 3/20 0.32
TP53 P04637 1/20 0.31
ADRA2A P08913 1/20 0.30
ADRA2B P18089 1/20 0.30
ADRA2C P18825 1/20 0.30
ADRA1A P35348 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL703702 0.79 SLC6A2 (0.40) SLC6A2TAAR1TSHRLMNACYP3A4
SCHEMBL17963379 0.72 TSHR (0.43) SLC6A2TAAR1MAOBTSHRMAOA
SCHEMBL49102 0.68 TP53 (0.42) TSHRCYP3A4ALDH1A1TP53
SCHEMBL1314806 0.66 SLC6A2 (0.43) SLC6A2TAAR1TSHRLMNACYP3A4
SCHEMBL9505652 0.66 TP53 (0.40) TSHRALDH1A1TP53
SCHEMBL28865582 0.66 KMT2A (0.47) TSHRCYP3A4ALDH1A1SMN1; SMN2CYP1A2
SCHEMBL4528233 0.65 SLC6A2 (0.52) SLC6A2TAAR1MAOBTSHRMAOA
SCHEMBL21112710 0.65 TP53 (0.39) TSHRCYP3A4ALDH1A1TP53
SCHEMBL18405594 0.65 CA4 (0.39) TSHRCYP3A4ALDH1A1CYP2D6CYP1A2
SCHEMBL123780 0.65 TP53 (0.44) SLC6A2TAAR1TSHRLMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0769513-B1 Curable resin composition NIPPON PAINT CO LTD (JP) 1999-11-17 EP disclosed
US-5741552-A FINISH COATINGS FOR AUTOMOBILES NIPPON PAINT CO., LTD. (JP) 1998-04-21 US disclosed
EP-0630943-B1 Curable resin composition NIPPON PAINT CO LTD (JP) 1998-01-28 EP disclosed
EP-0803529-A1 Curable resin composition NIPPON PAINT CO., LTD. (JP) 1997-10-29 EP disclosed
US-5674569-A CURING UNDERCOATINGS, CLEAR TOP COATINGS CONCURRENTLY OR SEPARATLY, THE TOP COATINGS COMPRISING A BLEND OF A RESIN WITH PLURAL HYDROSILYL GROUP OR A POLYHYDROGENSILOXANE HOMO-OR COPOLYMER NIPPON PAINT CO., LTD. (JP) 1997-10-07 US disclosed
EP-0769513-A1 Curable resin composition NIPPON PAINT CO., LTD. (JP) 1997-04-23 EP disclosed
US-5599883-A COATING MIXTURES ALSO CONTAINING HYDROSILATION CATALYST NIPPON PAINT CO., LTD. (JP) 1997-02-04 US disclosed
EP-0702068-A1 Method of forming multilayer coatings on a substrate Nippon Paint Co., Ltd. (JP) 1996-03-20 EP disclosed
EP-0630943-A2 Curable resin composition Nippon Paint Co., Ltd. (JP) 1994-12-28 EP disclosed